TY - JOUR
T1 - System identification and parameter estimation in mathematical medicine
T2 - examples demonstrated for prostate cancer
AU - Hirata, Yoshito
AU - Morino, Kai
AU - Suzuki, Taiji
AU - Guo, Qian
AU - Fukuhara, Hiroshi
AU - Aihara, Kazuyuki
N1 - Funding Information:
This research is partially supported by the Platform Project for Supporting in Drug Discovery and Life Science Research (Platform for Dynamic Approaches to Living System) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Japan Agency for Medical Research and Development (AMED), and CREST, JST. This research is also partially supported by JSPS KAKENHI Grant No. 15H05707. T. S. is supported by MEXT Kakenhi (Nos. 25730013, 25120012, and 26280009) and JST-PRESTO. Q. G. is supported by Natural Science Foundation of Shanghai (No. 14ZR1431300).
Publisher Copyright:
© 2016, Higher Education Press and Springer-Verlag GmbH.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - We review our studies on how to identify the most appropriate models of diseases, and how to determine their parameters in a quantitative manner given a short time series of biomarkers, using intermittent androgen deprivation therapy of prostate cancer as an example. Recently, it has become possible to estimate the specific parameters of individual patients within a reasonable time by employing the information concerning other previous patients as a prior.We discuss the importance of using multiple mathematical methods simultaneously to achieve a solid diagnosis and prognosis in the future practice of personalized medicine.
AB - We review our studies on how to identify the most appropriate models of diseases, and how to determine their parameters in a quantitative manner given a short time series of biomarkers, using intermittent androgen deprivation therapy of prostate cancer as an example. Recently, it has become possible to estimate the specific parameters of individual patients within a reasonable time by employing the information concerning other previous patients as a prior.We discuss the importance of using multiple mathematical methods simultaneously to achieve a solid diagnosis and prognosis in the future practice of personalized medicine.
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U2 - 10.1007/s40484-016-0059-0
DO - 10.1007/s40484-016-0059-0
M3 - Review article
AN - SCOPUS:85042686913
SN - 2095-4689
VL - 4
SP - 13
EP - 19
JO - Quantitative Biology
JF - Quantitative Biology
IS - 1
ER -
