Synthetic studies and properties of N-tert-butylaminoxyl nucleosides.

Mariko Aso; Toshiyuki Kaneko; Morihide Nakamura; Yasuhiro Matsui; Noboru Koga; Hiroshi Suemune

doi:10.1093/nass/3.1.9

Synthetic studies and properties of N-tert-butylaminoxyl nucleosides.

Mariko Aso, Toshiyuki Kaneko, Morihide Nakamura, Yasuhiro Matsui, Noboru Koga, Hiroshi Suemune

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We synthesized 5-N-tert-butylhydroxylamino-2'-deoxyuridine (9b) via lithium-halogen exchange reaction of sodium salt of 5-iodo-2'-deoxyuridine (8b). This procedure was applicable to synthesis of the corresponding uridine (9a) and N-benzoyl cytidine (13). Obtained 9b was converted into stable aminoxyl (5a) by treatment with Ag2O to study its properties as a novel spin-labeled nucleoside.

Original language	English
Pages (from-to)	9-10
Number of pages	2
Journal	Nucleic acids research. Supplement (2001)
Issue number	3
DOIs	https://doi.org/10.1093/nass/3.1.9
Publication status	Published - 2003

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1093/nass/3.1.9

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title = "Synthetic studies and properties of N-tert-butylaminoxyl nucleosides.",

abstract = "We synthesized 5-N-tert-butylhydroxylamino-2'-deoxyuridine (9b) via lithium-halogen exchange reaction of sodium salt of 5-iodo-2'-deoxyuridine (8b). This procedure was applicable to synthesis of the corresponding uridine (9a) and N-benzoyl cytidine (13). Obtained 9b was converted into stable aminoxyl (5a) by treatment with Ag2O to study its properties as a novel spin-labeled nucleoside.",

author = "Mariko Aso and Toshiyuki Kaneko and Morihide Nakamura and Yasuhiro Matsui and Noboru Koga and Hiroshi Suemune",

year = "2003",

doi = "10.1093/nass/3.1.9",

language = "English",

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journal = "Nucleic acids research. Supplement (2001)",

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T1 - Synthetic studies and properties of N-tert-butylaminoxyl nucleosides.

AU - Aso, Mariko

AU - Kaneko, Toshiyuki

AU - Nakamura, Morihide

AU - Matsui, Yasuhiro

AU - Koga, Noboru

AU - Suemune, Hiroshi

PY - 2003

Y1 - 2003

N2 - We synthesized 5-N-tert-butylhydroxylamino-2'-deoxyuridine (9b) via lithium-halogen exchange reaction of sodium salt of 5-iodo-2'-deoxyuridine (8b). This procedure was applicable to synthesis of the corresponding uridine (9a) and N-benzoyl cytidine (13). Obtained 9b was converted into stable aminoxyl (5a) by treatment with Ag2O to study its properties as a novel spin-labeled nucleoside.

AB - We synthesized 5-N-tert-butylhydroxylamino-2'-deoxyuridine (9b) via lithium-halogen exchange reaction of sodium salt of 5-iodo-2'-deoxyuridine (8b). This procedure was applicable to synthesis of the corresponding uridine (9a) and N-benzoyl cytidine (13). Obtained 9b was converted into stable aminoxyl (5a) by treatment with Ag2O to study its properties as a novel spin-labeled nucleoside.

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EP - 10

JO - Nucleic acids research. Supplement (2001)

JF - Nucleic acids research. Supplement (2001)

IS - 3

ER -

Synthetic studies and properties of N-tert-butylaminoxyl nucleosides.

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