TY - JOUR
T1 - Synthetic models for the active site of cytochrome P450
AU - Tani, Fumito
AU - Matsu-ura, Mikiya
AU - Nakayama, Shinya
AU - Naruta, Yoshinori
N1 - Funding Information:
This research was financially supported by Grant-in-Aids for COE Research (#08CE2005 to Y.N.), for Scientific Research on Priority Areas (#09235225 and 11228207 to Y.N.), and for Encouragement of Young Scientists (#08740500 to F.T.) from the Ministry of Education, Science and Culture, Japan and by Research Grants to Y.N. from the Sumitomo Foundation and to F.T. from the Takeda Science Foundation and Otsuka Chemical Co. Ltd.
PY - 2002
Y1 - 2002
N2 - As cytochrome P450 models, two kinds of iron porphyrins were synthesized, each of which has an alkanethiolate axial ligand and hydroxyl groups inside the molecular cavities. The stable dioxygen adducts were obtained by the reaction of the ferric complexes with KO2 under an oxygen atmosphere. This study first demonstrated a hydrogen bond to bound dioxygen in an oxy form of a thiolate-coordinated heme model system. These results are discussed in relation to the process of dioxygen binding and activation in cytochrome P450.
AB - As cytochrome P450 models, two kinds of iron porphyrins were synthesized, each of which has an alkanethiolate axial ligand and hydroxyl groups inside the molecular cavities. The stable dioxygen adducts were obtained by the reaction of the ferric complexes with KO2 under an oxygen atmosphere. This study first demonstrated a hydrogen bond to bound dioxygen in an oxy form of a thiolate-coordinated heme model system. These results are discussed in relation to the process of dioxygen binding and activation in cytochrome P450.
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U2 - 10.1016/S0010-8545(01)00444-1
DO - 10.1016/S0010-8545(01)00444-1
M3 - Article
AN - SCOPUS:0036197646
SN - 0010-8545
VL - 226
SP - 219
EP - 226
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
IS - 1-2
ER -