Synthesis of Transmembrane Molecules by Click Chemistry

Wataru Hatanaka, Hiroki Takeuchi, Minaho Koga, Taka-aki Ryujin, Akihiro Kishimura, Yoshiki Katayama, Shinya Tsukiji, Takeshi Mori

Research output: Contribution to journalArticlepeer-review


<p>We report here efficient synthesis of artificial transmembrane molecules (ATMs), via click chemistry of a transmembrane part and membrane-penetrating parts. Synthesized ATMs penetrated the cell membrane by Coulombic force, while they stayed on the cell membrane once they were complexed with streptavidin.</p>
Original languageEnglish
Pages (from-to)433-436
Number of pages4
JournalChemistry Letters
Issue number5
Publication statusPublished - 2019


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