Synthesis of the Right‐Side Structure of Type B Physalins

Masaki Morita, Shuntaro Kojima, Megumi Ohkubo, Hiroyuki Koshino, Daisuke Hashizume, Go Hirai, Keiji Maruoka, Mikiko Sodeoka

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


We present a full account of our synthetic studies on the racemic DEFGH-ring moiety of physalins, featuring domino ring transformation of a tricyclic key intermediate. We also report the results of a detailed mechanistic examination of the domino ring transformation, as well as a reoptimization of the 2,3-Wittig rearrangement and methylation steps. Furthermore, we have newly established a method for the preparation of an optically active synthetic intermediate by enzymatic kinetic resolution. Our work provides access to both natural and nonnatural right-side physalin structures.
Original languageEnglish
Pages (from-to)309-318
Number of pages10
JournalIsrael Journal of Chemistry
Issue number3-4
Publication statusPublished - 2017


Dive into the research topics of 'Synthesis of the Right‐Side Structure of Type B Physalins'. Together they form a unique fingerprint.

Cite this