TY - JOUR
T1 - Synthesis of the DFGH ring system of type B physalins
T2 - Highly oxygenated, cage-shaped molecules
AU - Ohkubo, Megumi
AU - Hirai, Go
AU - Sodeoka, Mikiko
PY - 2009/5/11
Y1 - 2009/5/11
N2 - Let the dominos fall: Synthesis of the complex DFGH ring system of the title compounds has been accomplished. The approach features simple treatment of the key intermediate with a Brønsted base to afford the tetracyclic cage-shaped target in one pot through a four-step domino transformation (see scheme; Mc= monochloromesylate, MOM=methoxymethyl).
AB - Let the dominos fall: Synthesis of the complex DFGH ring system of the title compounds has been accomplished. The approach features simple treatment of the key intermediate with a Brønsted base to afford the tetracyclic cage-shaped target in one pot through a four-step domino transformation (see scheme; Mc= monochloromesylate, MOM=methoxymethyl).
UR - http://www.scopus.com/inward/record.url?scp=70349970378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349970378&partnerID=8YFLogxK
U2 - 10.1002/anie.200900634
DO - 10.1002/anie.200900634
M3 - Article
C2 - 19378305
AN - SCOPUS:70349970378
SN - 1433-7851
VL - 48
SP - 3862
EP - 3866
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 21
ER -