@article{f7a5429a406d4a7ebcbd3f5c30ba2281,
title = "Synthesis of the deuterated thymidine-d9 and deuterated oligonucleotides",
abstract = "The efficient synthesis of the highly-deuterated thymidine-d9 by the glycosylation reaction between a deuterated nucleobase and deuterated sugar is described. It is also incorporated into the oligonucleotides using a DNA synthesizer. Using this approach, it is possible to make highly-deuterated oligonucleotides for biological studies and structural analyses.",
author = "Yosuke Taniguchi and Xiuming Cao and Shigeki Sasaki",
note = "Funding Information: Acknowledgments This study was supported by a Grant-in-Aid for Scientific Research (B) (Grant Number 19H03351 for Y.T.) and a Grant-in-Aid for Scientific Research (B) (18H02558 for S.S.), a Challenging Research (Exploratory) (Grant Number 17K19494 for Y.T.) from the Japan Society for the Promotion of Science (JSPS). Prof. Hironao Sajiki and Associate Prof. Yoshinari Sawama of Gifu Pharmaceutical University are thanked for the discussion of the synthetic deuteration reaction method. Funding Information: Acknowledgments This study was supported by a Grant-in-Aid for Scientific Research (B) (Grant Number 19H03351 for Y.T.) and a Grant-in-Aid for Scientific Research (B) (18H02558 for S.S.), a Challenging Research (Exploratory) (Grant Number 17K19494 for Y.T.) from the Japan Society for the Promotion of Science (JSPS). Prof. Hironao Sajiki and Associate Prof. Yoshinari Sawama of Gifu Pharmaceutical University are thanked for the discussion of the synthetic deuteration reaction method. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = sep,
day = "19",
doi = "10.1016/j.tetlet.2019.151037",
language = "English",
volume = "60",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "38",
}