TY - JOUR
T1 - Synthesis of the 1β-Methylcarbapenem Key Intermediates
AU - Ito, Yoshio
AU - Terashima, Shiro
PY - 1989
Y1 - 1989
N2 - The 1β-methylcarbapenem antibiotics represented by 3, 4, and 5, have been the focus of current synthetic endeavor due to prominent antibacterial activities and broad spectra as well as enhanced chemical and metabolic stability. Progress of the syntheses of 1β-methylcarbapenem key intermediates represented by 6, are reviewed based on the synthetic methods of the characteristic 1β-methyl substituent involved in the contiguous four chiral centers of 6.
AB - The 1β-methylcarbapenem antibiotics represented by 3, 4, and 5, have been the focus of current synthetic endeavor due to prominent antibacterial activities and broad spectra as well as enhanced chemical and metabolic stability. Progress of the syntheses of 1β-methylcarbapenem key intermediates represented by 6, are reviewed based on the synthetic methods of the characteristic 1β-methyl substituent involved in the contiguous four chiral centers of 6.
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U2 - 10.5059/yukigoseikyokaishi.47.606
DO - 10.5059/yukigoseikyokaishi.47.606
M3 - Article
AN - SCOPUS:85004434343
SN - 0037-9980
VL - 47
SP - 606
EP - 618
JO - Journal of Synthetic Organic Chemistry, Japan
JF - Journal of Synthetic Organic Chemistry, Japan
IS - 7
ER -