TY - JOUR
T1 - Synthesis of pectin-N, N-dimethyl acrylamide hydrogel by gamma radiation and application in drug delivery (in vitro)
AU - Bhuyan, Md Murshed
AU - Okabe, Hirotaka
AU - Hidaka, Yoshiki
AU - Dafader, Nirmal Chandra
AU - Rahman, Nazia
AU - Hara, Kazuhiro
N1 - Funding Information:
This work was supported by the JSPS KAKENHI (21656239, 24360398).
Funding Information:
The SEM measurements and gamma-ray irradiation were made at ‘Center of Advanced Instrumental Analysis’ and ‘Center for Accelerator and Beam Applied Science’ of Kyushu University, respectively. This work was supported by JSPS KAKENHI Grant Number 21656239, 24360398.
Publisher Copyright:
© 2018 Taylor & Francis Group, LLC.
PY - 2018/4/3
Y1 - 2018/4/3
N2 - The objective of the work is to synthesize pectin-N, N-Dimethylacrylamide (DMAA) hydrogel by gamma radiation without using any initiators and cross-linking agents. Effect of radiation doses on gel fraction and equilibrium swelling as a function of pH were studied, and 5 kGy radiation dose was found to be the optimum dose for hydrogel synthesis. The grafting /crosslinking was investigated by Fourier transform infrared spectroscopy. Thermal properties and surface morphology were studied by differential scanning calorimetry and scanning electron microscopy. To study the drug release kinetics, 5-fluorouracil was loaded into the hydrogel and in vitro release was carried out in simulated gastric and intestinal fluid. The release profile of drug showed that more than 90% of the loaded drugs were released after 4 hours at both gastric fluid and intestinal fluid pH. Drug release data was fitted into zero order, Higuchi and Korsmeyer-Peppas kinetic models. Higuchi model was found to be the best fitted and release exponent ‘n’ value of Korsmeyer-Peppas model indicated the non-Fickian transport.
AB - The objective of the work is to synthesize pectin-N, N-Dimethylacrylamide (DMAA) hydrogel by gamma radiation without using any initiators and cross-linking agents. Effect of radiation doses on gel fraction and equilibrium swelling as a function of pH were studied, and 5 kGy radiation dose was found to be the optimum dose for hydrogel synthesis. The grafting /crosslinking was investigated by Fourier transform infrared spectroscopy. Thermal properties and surface morphology were studied by differential scanning calorimetry and scanning electron microscopy. To study the drug release kinetics, 5-fluorouracil was loaded into the hydrogel and in vitro release was carried out in simulated gastric and intestinal fluid. The release profile of drug showed that more than 90% of the loaded drugs were released after 4 hours at both gastric fluid and intestinal fluid pH. Drug release data was fitted into zero order, Higuchi and Korsmeyer-Peppas kinetic models. Higuchi model was found to be the best fitted and release exponent ‘n’ value of Korsmeyer-Peppas model indicated the non-Fickian transport.
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U2 - 10.1080/10601325.2018.1442177
DO - 10.1080/10601325.2018.1442177
M3 - Article
AN - SCOPUS:85042939340
SN - 1060-1325
VL - 55
SP - 369
EP - 376
JO - Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
JF - Journal of Macromolecular Science, Part A: Pure and Applied Chemistry
IS - 4
ER -