Synthesis of amphiphilic lactose-substituted polyether dendrimers

Keigo Aoi, Takaaki Fukui, Yoshiharu Otsuka, Tadao Kondo, Keiji Tanaka, Toshihiko Nagamura

    Research output: Contribution to conferencePaperpeer-review


    Previously, we reported synthesis of amphiphilic polyether dendrimers having a sugar residue at the core, designed to create a new biomedical material with controlled sugar alleys having intervals on a nanoscale by organization, and the plane arrangement of the dendrimers was shown to be able to control at nano-level. In this report, we synthesized amphiphilic n-decyl-terminal polyether dendrimers having a lactose or galactose residue at the core. The core-lactose- or galactose-substituted poly(ethylene glycol) dendrimer was afforded by Schmidt glycosylation between the core-hydroxy-type n-decyl-terminal aliphatic polyether dendrimer and 4-0-(2,3,4,6-tetra-O-acetyl-β-D- galactopyranosyl)-2,3,6-tri-O-acetyl-α-D-glucopyranosyl trichloroacetimidate or 2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl trichloroacetimidate followed by deacetylation. Chemical structures of the dendrimers were determined by1H-NMR, 1H-1H COSY and MALDI-TOF MS analyses.

    Original languageEnglish
    Number of pages1
    Publication statusPublished - Dec 1 2005
    Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
    Duration: May 25 2005May 27 2005


    Other54th SPSJ Annual Meeting 2005

    All Science Journal Classification (ASJC) codes

    • Engineering(all)


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