TY - JOUR
T1 - Synthesis of a trans-chelating chiral diphosphine ligand with only planar chirality and its application to asymmetric hydrosilylation of ketones
AU - Kuwano, R.
AU - Uemura, T.
AU - Saitoh, M.
AU - Ito, Y.
PY - 1999/2/12
Y1 - 1999/2/12
N2 - Optically active diphosphine (S,S)-2,2-bis[(diethylphosphino)methyl]- 1,1-biferrocene (abbreviated to (S,S)-EtTRAP-H) was synthesized from ferrocenyloxazoline derived from-L-valinol in 47% overall yield. The new chiral ligand, (S,S)-EtTRAP-H, which coordinates to a rhodium atom in a trans-chelating manner, was effective for asymmetric hydrosilylation of ketones to give optically active secondary alcohols with up to 94% ee.
AB - Optically active diphosphine (S,S)-2,2-bis[(diethylphosphino)methyl]- 1,1-biferrocene (abbreviated to (S,S)-EtTRAP-H) was synthesized from ferrocenyloxazoline derived from-L-valinol in 47% overall yield. The new chiral ligand, (S,S)-EtTRAP-H, which coordinates to a rhodium atom in a trans-chelating manner, was effective for asymmetric hydrosilylation of ketones to give optically active secondary alcohols with up to 94% ee.
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U2 - 10.1016/S0040-4039(98)02603-3
DO - 10.1016/S0040-4039(98)02603-3
M3 - Article
AN - SCOPUS:0033547994
SN - 0040-4039
VL - 40
SP - 1327
EP - 1330
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 7
ER -