Novel purine ribonucleosides with a tert-butylhydroxy-amino function at the C8-position of the purine nucleus were synthesized, and were oxidized to aminoxyl radicals by treatment with Ag2O; after O-acylation of the tert-butylhydroxyamino group, nucleophilic substitution at the C2-position of the purine nucleus easily proceeded with elimination of the N-acyloxy group to provide a novel method for preparing C2-functionalized purine ribonucleosides.
|Number of pages
|Journal of the Chemical Society. Perkin Transactions 2
|Published - Aug 2000
All Science Journal Classification (ASJC) codes
- General Chemistry