Synthesis of a high-mannose-type glycopeptide analog containing a glucose-asparagine linkage

Ina L. Deras; Kaoru Takegawa; Akihiro Kondo; Ikunoshin Kato; Yuan C. Lee

doi:10.1016/S0960-894X(98)00306-0

Synthesis of a high-mannose-type glycopeptide analog containing a glucose-asparagine linkage

Ina L. Deras, Kaoru Takegawa, Akihiro Kondo, Ikunoshin Kato, Yuan C. Lee

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

The title compound was prepared by enzymatic transfer of oligosaccharide to a synthetic pentapeptide containing the Glc-Asn linkage. The compound was not hydrolyzed by glycoamidases from plant and bacterial sources, but it inhibited both enzymes in the micromolar range. Its activity is compared to other potential inhibitors.

Original language	English
Pages (from-to)	1763-1766
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(98)00306-0
Publication status	Published - Jul 7 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(98)00306-0

Cite this

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title = "Synthesis of a high-mannose-type glycopeptide analog containing a glucose-asparagine linkage",

abstract = "The title compound was prepared by enzymatic transfer of oligosaccharide to a synthetic pentapeptide containing the Glc-Asn linkage. The compound was not hydrolyzed by glycoamidases from plant and bacterial sources, but it inhibited both enzymes in the micromolar range. Its activity is compared to other potential inhibitors.",

author = "Deras, {Ina L.} and Kaoru Takegawa and Akihiro Kondo and Ikunoshin Kato and Lee, {Yuan C.}",

note = "Funding Information: Acknowledgments. The authors thank Dr. Mei Tang for the gift of fetuin glycopeptide. supported in part by NIH Research grant DK09970.",

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T1 - Synthesis of a high-mannose-type glycopeptide analog containing a glucose-asparagine linkage

AU - Deras, Ina L.

AU - Takegawa, Kaoru

AU - Kondo, Akihiro

AU - Kato, Ikunoshin

AU - Lee, Yuan C.

N1 - Funding Information: Acknowledgments. The authors thank Dr. Mei Tang for the gift of fetuin glycopeptide. supported in part by NIH Research grant DK09970.

PY - 1998/7/7

Y1 - 1998/7/7

N2 - The title compound was prepared by enzymatic transfer of oligosaccharide to a synthetic pentapeptide containing the Glc-Asn linkage. The compound was not hydrolyzed by glycoamidases from plant and bacterial sources, but it inhibited both enzymes in the micromolar range. Its activity is compared to other potential inhibitors.

AB - The title compound was prepared by enzymatic transfer of oligosaccharide to a synthetic pentapeptide containing the Glc-Asn linkage. The compound was not hydrolyzed by glycoamidases from plant and bacterial sources, but it inhibited both enzymes in the micromolar range. Its activity is compared to other potential inhibitors.

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IS - 13

ER -

Synthesis of a high-mannose-type glycopeptide analog containing a glucose-asparagine linkage

Abstract

All Science Journal Classification (ASJC) codes

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