Synthesis of 4-quinolones through nickel-catalyzed intramolecular amination on the β-carbon of o-(N-alkylamino)propiophenones

Satoshi Ueno; Ryosuke Shimizu; Ryohei Maeda; Ryoichi Kuwano

doi:10.1055/s-0031-1291146

Synthesis of 4-quinolones through nickel-catalyzed intramolecular amination on the β-carbon of o-(N-alkylamino)propiophenones

Satoshi Ueno
, Ryosuke Shimizu
, Ryohei Maeda
, Ryoichi Kuwano

Multidisciplinary chemistry

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

o-(N-Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of β-enaminones from o-(N-alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.

Original language	English
Pages (from-to)	1639-1642
Number of pages	4
Journal	Synlett
Volume	23
Issue number	11
DOIs	https://doi.org/10.1055/s-0031-1291146
Publication status	Published - 2012

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1055/s-0031-1291146

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title = "Synthesis of 4-quinolones through nickel-catalyzed intramolecular amination on the β-carbon of o-(N-alkylamino)propiophenones",

abstract = "o-(N-Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of β-enaminones from o-(N-alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.",

author = "Satoshi Ueno and Ryosuke Shimizu and Ryohei Maeda and Ryoichi Kuwano",

year = "2012",

doi = "10.1055/s-0031-1291146",

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publisher = "Georg Thieme Verlag",

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T1 - Synthesis of 4-quinolones through nickel-catalyzed intramolecular amination on the β-carbon of o-(N-alkylamino)propiophenones

AU - Ueno, Satoshi

AU - Shimizu, Ryosuke

AU - Maeda, Ryohei

AU - Kuwano, Ryoichi

PY - 2012

Y1 - 2012

N2 - o-(N-Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of β-enaminones from o-(N-alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.

AB - o-(N-Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of β-enaminones from o-(N-alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.

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UR - https://www.scopus.com/pages/publications/84862152692#tab=citedBy

U2 - 10.1055/s-0031-1291146

DO - 10.1055/s-0031-1291146

M3 - Article

AN - SCOPUS:84862152692

SN - 0936-5214

VL - 23

SP - 1639

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JO - Synlett

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ER -

Synthesis of 4-quinolones through nickel-catalyzed intramolecular amination on the β-carbon of o-(N-alkylamino)propiophenones

Abstract

All Science Journal Classification (ASJC) codes

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