Synthesis of 20‐[18F]fluoroarachidonic acid: A potential phospholipid metabolic agent

Fumi Nagatsugi; Junji Hokazono; Shigeki Sasaki; Minoru Maeda

doi:10.1002/jlcr.2580341202

Synthesis of 20‐[¹⁸F]fluoroarachidonic acid: A potential phospholipid metabolic agent

Fumi Nagatsugi, Junji Hokazono, Shigeki Sasaki, Minoru Maeda

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A fluorine‐18 labelled analog of arachidonic acid, 20‐[¹⁸F]fluoroarachidonic acid, was prepared for evaluation as a potential phospholipid metabolic agent. The radiosynthesis was accomplished by [¹⁸F]fluoride ion displacement on the tosylate precursor followed by basic hydrolysis of the ester group, in isolated radiochemical yield (not decay corrected) of 10 % in overall synthesis time (including HPLC purification) of 110 min.

Original language	English
Pages (from-to)	1121-1127
Number of pages	7
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	34
Issue number	12
DOIs	https://doi.org/10.1002/jlcr.2580341202
Publication status	Published - Dec 1994

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

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abstract = "A fluorine‐18 labelled analog of arachidonic acid, 20‐[18F]fluoroarachidonic acid, was prepared for evaluation as a potential phospholipid metabolic agent. The radiosynthesis was accomplished by [18F]fluoride ion displacement on the tosylate precursor followed by basic hydrolysis of the ester group, in isolated radiochemical yield (not decay corrected) of 10 % in overall synthesis time (including HPLC purification) of 110 min.",

author = "Fumi Nagatsugi and Junji Hokazono and Shigeki Sasaki and Minoru Maeda",

year = "1994",

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AU - Sasaki, Shigeki

AU - Maeda, Minoru

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AB - A fluorine‐18 labelled analog of arachidonic acid, 20‐[18F]fluoroarachidonic acid, was prepared for evaluation as a potential phospholipid metabolic agent. The radiosynthesis was accomplished by [18F]fluoride ion displacement on the tosylate precursor followed by basic hydrolysis of the ester group, in isolated radiochemical yield (not decay corrected) of 10 % in overall synthesis time (including HPLC purification) of 110 min.

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Synthesis of 20‐[¹⁸F]fluoroarachidonic acid: A potential phospholipid metabolic agent

Abstract

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