Synthesis of ω-fluorinated octanoic acid and its β-substituted derivatives

Simple syntheses are described for the ω-fluorinated analogs of octanoic acid and its β-substituted derivatives in which insertion of a methyl and dimethyl group, and oxygen substitution at the C-3 position are involved, employing nucleophilic displacement with fluoride ion of the tosylate functions in the later stage of synthesis. The synthetic procedures offer easy and convenient access to the corresponding ¹⁸F-labeled analogs using the readily available [¹⁸F]fluoride ion.