Synthesis of α,α-dibromo esters as precursors of ynolates

Mitsuru Shindo, Yusuke Sato, Ryoko Koretsune, Takashi Yoshikawa, Kenji Matsumoto, Kotaro Itoh, Kozo Shishido

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Aliphatic α,α-dibromo esters, precursors of ynolates, were synthesized via bromination of lithium α-bromo ester enolates with 1,2-dibromotetrafluoroethane in good yields. α-Trimethylsilyl-α, α-dibromo esters were synthesized via radical bromination.

Original languageEnglish
Pages (from-to)477-478
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Issue number4
Publication statusPublished - Apr 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Drug Discovery


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