Synthesis and structural characterization of nanoapatite ceramics powders for biomedical applications

Kanae Ando, Mizuki Ohkubo, Satoshi Hayakawa, Kanji Tsuru, Akiyoshi Osaka, Eiji Fujii, Koji Kawabata, Christian Bonhomme, Florence Babonneau

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)


Zn/HAp particles were prepared by soaking hydroxyapatite (HAp), derived through a wet chemical method, into aqueous solutions containing various amounts of zinc nitrate. Obtained samples were characterized by inductively coupled plasma emission spectroscopy, X-ray diffraction (XRD), Brunauer-Emmett-Teller surface area analysis (SA), and transmission electron microscopy. Their zeta potential was also measured. The analyzed Zn content was almost proportional to the content in the aqueous solutions. The Zn 2+ ions were partially replaced the Ca 2+ ions in the apatite, and hence, little change was observed in crystallinity, particle size and SA. Adsorption of bovine serum albumin (BSA) and ß 2-microglobulin (ß 2-MG) in the solutions containing both BSA and ß 2-MG was examined. As the Zn 2+ ion content in the apatites increased, the adsorbed amount of BSA was almost constant, whereas that of ß 2-MG increased. Thus, the Zn incorporation increased the selectivity, and it is suggested that the Zn-substituted site should be the active ones for ß 2-MG adsorption.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalCeramic Transactions
Publication statusPublished - 2006
Externally publishedYes
Event6th Pacific Rim Conference on Ceramic and Glass Technology, PacRim6 - Maui, HI, United States
Duration: Sept 11 2005Sept 16 2005

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Materials Chemistry


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