TY - JOUR
T1 - Synthesis and relaxivities of oligonucleotides with TEMPO-labeled sugar moiety
AU - Okazaki, Manami
AU - Sato, Yuichiro
AU - Karasawa, Satoru
AU - Koga, Noboru
PY - 2008
Y1 - 2008
N2 - 5-Uridin derivative, UUT, having TEMPO radical at the 2'-position of sugar moiety, was prepared and characterized by X-ray crystallography. The single strands, ssUUT, incorporating UUT and the double strands, dsUUT, with complimentary strand were also obtained. Their EPR spectra and relaxivities (25 MHz and 0.59 T) in water were measured. The values of tau R obtained from the simulation of EPR spectra and the water-proton relaxivities, r1 and r2, increased in order of UUT, ssUUT, and dsUUT.
AB - 5-Uridin derivative, UUT, having TEMPO radical at the 2'-position of sugar moiety, was prepared and characterized by X-ray crystallography. The single strands, ssUUT, incorporating UUT and the double strands, dsUUT, with complimentary strand were also obtained. Their EPR spectra and relaxivities (25 MHz and 0.59 T) in water were measured. The values of tau R obtained from the simulation of EPR spectra and the water-proton relaxivities, r1 and r2, increased in order of UUT, ssUUT, and dsUUT.
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U2 - 10.1093/nass/nrn189
DO - 10.1093/nass/nrn189
M3 - Article
C2 - 18776410
AN - SCOPUS:78649430819
SN - 1746-8272
SP - 375
EP - 376
JO - Nucleic acids symposium series (2004)
JF - Nucleic acids symposium series (2004)
IS - 52
ER -