TY - JOUR
T1 - Synthesis and insecticidal activity of optically active 2-methoxy- 5-phenyl-1, 3, 2-oxazaphospholidine 2-sulfide
AU - Wu, Shao Yong
AU - Hirashima, Akinori
AU - Takeya, Ryuko
AU - Eto, Morifusa
N1 - Funding Information:
Insecticidal tests. Two strains of house fly (Musca domestica were used for the bioassay. They were the WHO standard susceptible strain (SRS) and resistant strain (3-Y F) obtained by rearing the 3rd Yumenoshima (3-Y) strain under fenitrothion pressure for ten successive generations. Three-to five-day-old female adults were used for the insecticidal test, which was carried out by topically treating the house flies with 1 III of an acetone solution of the test chemicals as previously reported.IO) Acknowledgment. This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Agriculture, Forestry and Fishery of Japan.
PY - 1989/1
Y1 - 1989/1
N2 - Four optically active isomers (optical purity >94.6% d.e.) of 2-methoxy-5-phenyl-l, 3, 2- oxazaphospholidine 2-sulfide (5-PMOS) were synthesized by a two-step phosphorylating method, and their insecticidal activities were determined against susceptible (SRS) and resistant (3-YF) strains of house flies by topical application. The relationship between the configuration and insecticidal activity was similar in the susceptible and resistant strains of house flies. The (R)C(R)P-isomer showed the highest insecticidal activity, followed by (R)C(S)P>(S)C(R)P>(S)C(S)P.
AB - Four optically active isomers (optical purity >94.6% d.e.) of 2-methoxy-5-phenyl-l, 3, 2- oxazaphospholidine 2-sulfide (5-PMOS) were synthesized by a two-step phosphorylating method, and their insecticidal activities were determined against susceptible (SRS) and resistant (3-YF) strains of house flies by topical application. The relationship between the configuration and insecticidal activity was similar in the susceptible and resistant strains of house flies. The (R)C(R)P-isomer showed the highest insecticidal activity, followed by (R)C(S)P>(S)C(R)P>(S)C(S)P.
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U2 - 10.1080/00021369.1989.10869278
DO - 10.1080/00021369.1989.10869278
M3 - Article
AN - SCOPUS:0005118446
SN - 0002-1369
VL - 53
SP - 165
EP - 174
JO - Agricultural and Biological Chemistry
JF - Agricultural and Biological Chemistry
IS - 1
ER -