Synthesis and Characterization of Sol-Gel Derived Strontium Doped S53P4 Bioglass

Swe Thet Thet, Mohamad Hasmaliza, Anuar Shariff Khairul, Ishikawa Kunio

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

This study concerns the evaluation of the bioactivity and cells response of strontium (Sr) doped sol-gel derived S53P4 bioglass due to Sr induced osteoblast. Moreover it prevents in-vitro osteoclastic activity and is clinically used as osteoporosis treatment. The different amount of Sr was doped into the S53P4 bioglass formulation (53.82%SiO2-1.72%P2O5-22.64%Na2O-(21.76-x)%CaO-x%SrO) (x=0, 3 and 5 mol %) and synthesized via sol-gel method. These samples were denoted as 0Sr, 3Sr and 5Sr respectively. After soaking in Hank's balanced salt solution (HBSS) for 7 and 14 days, the apatite formation was examined using X-ray powder diffraction (XRD) and scanning electron microscope (SEM) techniques. Proliferation and alkaline phosphatase activity were evaluated using osteoblastic cell line MC3T3-E1. The XRD and SEM findings confirmed the hydroxyapatite (HA) structure on the bioglass surface after soaking. More intense HA peaks were observed in 3Sr specimen on 7 day while in 5Sr specimen on 14 day. Meanwhile, 3Sr specimen showed the highest cells proliferation and significant difference in alkaline phosphatase (ALP) activity than 0Sr and 5Sr. As a result, this finding indicates that S53P4 bioglass with 3 mol % SrO (3Sr) is a good candidate for bone tissue engineering because it allows for optimum cell proliferation and ALP activity while also having a high bioactivity efficiency.

Original languageEnglish
Title of host publicationCurrent Materials Research Using X-Rays and Related Techniques III - Selected peer-reviewed full text papers from the 10th International Conference on X-Rays and Related Techniques in Research and Industry, ICXRI 2021
EditorsMuhamad Faiz Md Din, Fakhroul Ridzuan Hashim, Nazrul Fariq Makmor, Norazharuddin Shah Abdullah, Wan Fahmin Faiz Wan Ali, Nik Akmar Rejab, Muhammad Azwadi Sulaiman
PublisherTrans Tech Publications Ltd
Pages141-147
Number of pages7
ISBN (Print)9783035712742
DOIs
Publication statusPublished - 2022
Event10th International Conference on X-Rays and Related Techniques in Research and Industry, ICXRI 2021 - Virtual, Online
Duration: Aug 18 2021Aug 19 2021

Publication series

NameKey Engineering Materials
Volume908 KEM
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Conference

Conference10th International Conference on X-Rays and Related Techniques in Research and Industry, ICXRI 2021
CityVirtual, Online
Period8/18/218/19/21

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering

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