Synthesis and characterization of polysaccharide-oligonucleotide conjugate

Naoya Fukuda, Naohiko Shimada, Seiji Shinkai, Kazuo Sakurai

Research output: Contribution to conferencePaperpeer-review


We have reported that SPG can from a complex with oligodeoxynucleotide (ODN) attaching (<A20) tail at 3′ end. However, SPG cannot form the complex with ODN attaching short tail (<dAso) due to reduction of thermodynamic stability. In this study, we examined whether ODN-conjugated SPG can form an intramolecular complex. dA20 was introduced to reducing terminal of SPG via diaminoalkanes or diaminoPEGs. The conjugates were purified by gel-filtration. CD spectrum of the conjugate indicated a formation of intramolecular complex.

Original languageEnglish
Number of pages1
Publication statusPublished - 2006
Externally publishedYes
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: Sept 20 2006Sept 22 2006


Other55th Society of Polymer Science Japan Symposium on Macromolecules

All Science Journal Classification (ASJC) codes

  • Engineering(all)


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