Synthesis and assembly of amphiphilic polyether dendrimers having a disaccharide residue at the core

Takaaki Fukui, Yoshiharu Otsuka, Keigo Aoi, Keiji Tanaka, Toshihiko Nagamura

    Research output: Contribution to conferencePaperpeer-review


    We have already reported synthesis of amphiphilic polyether dendrimers having a sugar residue at the core, designed to create a new biomedical material with controlled sugar alleys having intervals on a nanoscale by organization, and the plane arrangement of the dendrimers was shown to be able to control at nano-level. In this report, we synthesized amphiphilic n-decyl-terminal polyether dendrimers having a lactose or galactose residue at the core for targeting liver cell. The core-lactose- or galactose-substituted poly(ethylene glycol) dendrimer was afforded by Schmidt glycosylation between the core-hydroxy-type n-decyl-terminal aliphatic polyether dendrimer and 4-0-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-2,3,6-tri-O-benzoyl- α-Dglucopyranosyl trichloroacetimidate or 2,3,4,6-tetra-O-acetyl-α- D-galactopyranosyl trichloroacetimidate followed by deprotection. Chemical structures of the dendrimers were determined by 1H-NMR and MALDI-TOF MS analyses.

    Original languageEnglish
    Number of pages1
    Publication statusPublished - 2005
    Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
    Duration: Sept 20 2005Sept 22 2005


    Other54th SPSJ Symposium on Macromolecules

    All Science Journal Classification (ASJC) codes

    • Engineering(all)


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