Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

Kinichi Nakashima, Makoto Yanagisawa, Hirokazu Arakawa, Naoki Kimura, Tatsuhiro Hisatsune, Masahiro Kawabata, Kohei Miyazono, Tetsuya Taga

Research output: Contribution to journalArticlepeer-review

747 Citations (Scopus)


The cytokines LIF (leukemia inhibitory factor) and BMP2 (bone morphogenetic protein-2) signal through different receptors and transcription factors, namely STATs (signal transducers and activators of transcription) and Smads. LIF and BMP2 were found to act in synergy on primary fetal neural progenitor cells to induce astrocytes. The transcriptional coactivator p300 interacts physically with STAT3 at its amino terminus in a cytokine stimulation-independent manner, and with Smad1 at its carboxyl terminus in a cytokine stimulation-dependent manner. The formation of a complex between STAT3 and Smad1, bridged by p300, is involved in the cooperative signaling of LIF and BMP2 and the subsequent induction of astrocytes from neural progenitors.

Original languageEnglish
Pages (from-to)479-482
Number of pages4
Issue number5413
Publication statusPublished - Apr 16 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General


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