TY - JOUR
T1 - Survey of anticancer drug exposure to attendant families in pediatric medical centers
AU - Noda, Yuko
AU - Koga, Yuhki
AU - Ohta, Momoe
AU - Miyazono, Mami
AU - Wakasugi, Yoko
AU - Funakoshi, Yukie
AU - Urabe, Yuki
AU - Kifune, Miho
AU - Ueda, Tamaki
AU - Oba, Utako
AU - Nakashima, Kentaro
AU - Souzaki, Ryota
AU - Kinoshita, Yoshiaki
AU - Taguchi, Tomoaki
AU - Ohga, Shouichi
N1 - Publisher Copyright:
© 2018 Japanese Journal of Cancer and Chemotherapy Publishers Inc. All rights reserved.
PY - 2018/6
Y1 - 2018/6
N2 - The occupational exposure to hazardous drugs (HD) has already been investigated; however, the actual exposure of the attendant family members of patients with childhood cancer has remained unknown. Here, we analyzed cyclophosphamide (CPM) exposure in attendant family members and the environment after the administration of CPM to patients with pediatric cancer. CPM of 320 (8.39-1, 510) ng from infant-families and 0 (0-58.4) ng from adolescent-families were detected (p= 0.01). The exposure of infant-families was significantly greater than those of adolescent-families. In addition, CPM were detected in the hot water after bathing the infant, underwear, and sheets. We elucidated that the exposures take place through body fluid and excretions of the children. In the field of childhood cancer, HD exposure measures should be taken according to the age of the child to minimize health damage to medical personnel, family members, and other children who share the room. Nurses are recommended to educate the patients and their family members about preventing exposure to HD in pediatric medical centers.
AB - The occupational exposure to hazardous drugs (HD) has already been investigated; however, the actual exposure of the attendant family members of patients with childhood cancer has remained unknown. Here, we analyzed cyclophosphamide (CPM) exposure in attendant family members and the environment after the administration of CPM to patients with pediatric cancer. CPM of 320 (8.39-1, 510) ng from infant-families and 0 (0-58.4) ng from adolescent-families were detected (p= 0.01). The exposure of infant-families was significantly greater than those of adolescent-families. In addition, CPM were detected in the hot water after bathing the infant, underwear, and sheets. We elucidated that the exposures take place through body fluid and excretions of the children. In the field of childhood cancer, HD exposure measures should be taken according to the age of the child to minimize health damage to medical personnel, family members, and other children who share the room. Nurses are recommended to educate the patients and their family members about preventing exposure to HD in pediatric medical centers.
UR - http://www.scopus.com/inward/record.url?scp=85052701970&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052701970&partnerID=8YFLogxK
M3 - Article
C2 - 30026419
AN - SCOPUS:85052701970
SN - 0385-0684
VL - 45
SP - 945
EP - 948
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
IS - 6
ER -
