TY - JOUR
T1 - Surgical resection for lymph node metastasis after liver transplantation for hepatocellular carcinoma
AU - Ikegami, Toru
AU - Yoshizumi, Tomoharu
AU - Kawasaki, Jyunji
AU - Nagatsu, Akihisa
AU - Uchiyama, Hideaki
AU - Harada, Noboru
AU - Harimoto, Norifumi
AU - Itoh, Shinji
AU - Motomura, Takashi
AU - Soejima, Yuji
AU - Maehara, Yoshihiko
PY - 2017
Y1 - 2017
N2 - Background: Treatment strategies for lymph node (LN) metastasis after liver transplantation (LT) for hepatocellular carcinoma (HCC) have not been studied. Patients and Methods: The treatment modes and outcomes in patients with LN metastasis after LT (n=6) for HCC were reviewed. Results: The mean time from LT to LN recurrence was 2.0±1.3 years, and the locations of the LNs recurrences included the phrenic (n=2), common hepatic artery (n=2), inferior vena cava (n=1) and gastric (n=1) regions. Treatments included surgery alone (n=3), surgery followed by chemoradiation (n=1), radiation followed by chemotherapy (n=1), and chemotherapy, radiation and sorafenib (n=1). Although the patients receiving nonsurgical treatments (n=3) died within 1.2 years, those who underwent surgical removal of the metastatic LNs survived 11.2 years, 4.5 years and 0.8 years, respectively, without any signs of re-recurrence. Conclusion: Surgical resection is the only feasible and potentially curative treatment for LN metastasis after LT for HCC.
AB - Background: Treatment strategies for lymph node (LN) metastasis after liver transplantation (LT) for hepatocellular carcinoma (HCC) have not been studied. Patients and Methods: The treatment modes and outcomes in patients with LN metastasis after LT (n=6) for HCC were reviewed. Results: The mean time from LT to LN recurrence was 2.0±1.3 years, and the locations of the LNs recurrences included the phrenic (n=2), common hepatic artery (n=2), inferior vena cava (n=1) and gastric (n=1) regions. Treatments included surgery alone (n=3), surgery followed by chemoradiation (n=1), radiation followed by chemotherapy (n=1), and chemotherapy, radiation and sorafenib (n=1). Although the patients receiving nonsurgical treatments (n=3) died within 1.2 years, those who underwent surgical removal of the metastatic LNs survived 11.2 years, 4.5 years and 0.8 years, respectively, without any signs of re-recurrence. Conclusion: Surgical resection is the only feasible and potentially curative treatment for LN metastasis after LT for HCC.
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U2 - 10.21873/anticanres.11395
DO - 10.21873/anticanres.11395
M3 - Article
C2 - 28179348
AN - SCOPUS:85013658522
SN - 0250-7005
VL - 37
SP - 891
EP - 896
JO - Anticancer research
JF - Anticancer research
IS - 2
ER -
