Surface plasmon resonance in monitoring of complement activation on biomaterials

Yusuke Arima, Mitsuaki Toda, Hiroo Iwata

Research output: Contribution to journalReview articlepeer-review

29 Citations (Scopus)


When artificial materials come into contact with blood, various biological responses are induced. For successful development of biomaterials used in biomedical devices that will be exposed to blood, understanding and control of these interactions are essential. Surface plasmon resonance (SPR) spectroscopy is one of the surface-sensitive optical methods to monitor biological interactions. SPR enables real-time and in situ analysis of interfacial events associated with biomaterials research. In this review, we describe an SPR biosensor and its application to monitor complement activation onto biomaterials surface. We also discuss the effect of surface properties of the material on complement activation.

Original languageEnglish
Pages (from-to)988-999
Number of pages12
JournalAdvanced Drug Delivery Reviews
Issue number12
Publication statusPublished - Sept 16 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


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