TY - JOUR
T1 - Surface plasmon resonance in monitoring of complement activation on biomaterials
AU - Arima, Yusuke
AU - Toda, Mitsuaki
AU - Iwata, Hiroo
N1 - Funding Information:
This study was partly supported by a Grant-in-Aid for Scientific Research (A) ( No. 21240051 ) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan, by a project of Kyoto City Collaboration of Regional Entities for the Advancement of Technological Excellence , and by Development of Systems and Technology for Advanced Measurement and Analysis, JST, Japan .
PY - 2011/9/16
Y1 - 2011/9/16
N2 - When artificial materials come into contact with blood, various biological responses are induced. For successful development of biomaterials used in biomedical devices that will be exposed to blood, understanding and control of these interactions are essential. Surface plasmon resonance (SPR) spectroscopy is one of the surface-sensitive optical methods to monitor biological interactions. SPR enables real-time and in situ analysis of interfacial events associated with biomaterials research. In this review, we describe an SPR biosensor and its application to monitor complement activation onto biomaterials surface. We also discuss the effect of surface properties of the material on complement activation.
AB - When artificial materials come into contact with blood, various biological responses are induced. For successful development of biomaterials used in biomedical devices that will be exposed to blood, understanding and control of these interactions are essential. Surface plasmon resonance (SPR) spectroscopy is one of the surface-sensitive optical methods to monitor biological interactions. SPR enables real-time and in situ analysis of interfacial events associated with biomaterials research. In this review, we describe an SPR biosensor and its application to monitor complement activation onto biomaterials surface. We also discuss the effect of surface properties of the material on complement activation.
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U2 - 10.1016/j.addr.2011.06.018
DO - 10.1016/j.addr.2011.06.018
M3 - Review article
C2 - 21803085
AN - SCOPUS:80052150500
SN - 0169-409X
VL - 63
SP - 988
EP - 999
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
IS - 12
ER -