Supramolecular systems composed of α-helical peptides

Yukio Imanishi, Katsuhiko Fujita, Yoshiko Miura, Shunsaku Kimura

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12 Citations (Scopus)


Hydrophobic helical peptides having alternating hydrophobic amino acid and Aib in the sequence were synthesized to construct supramolecular systems. Three types of supramolecular systems were constructed by the peptides and the derivatives in different environments. First, the dispersion of TFA·H-(Ala-Aib)8-OBzl in water was studied by dynamic light scattering, which suggests the formation of a vesicular structure with an average diameter of 76 nm. We call the peptide assembly in water `peptosome'. Second, Boc-Ser(Ant)-(Ala-Aib)8-OMe spanned the phospholipid bilayer membrane and formed a helix-bundle structure. The bundle structure was supported by ion-channel formation in the membrane. Third, Boc-(Ala-Aib)8-OMe and Boc-(Leu-Aib)8-OBzl formed a two-dimensional crystal at the air-water interface. Boc-(Ala-Aib)12-OBzl also formed a monolayer in a solid state at the air-water interface, but the helix orientation was perpendicular to the interface, which presents a contrast to the parallel orientation of the former hexadecapeptides.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalSupramolecular Science
Issue number1-3
Publication statusPublished - 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Engineering(all)


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