TY - GEN
T1 - Suppression of band broadening in monodispersed and polydispersed micropillar array columns in liquid chromatography
AU - Iwaba, T.
AU - Naito, T.
AU - Kubo, T.
AU - Otsuka, K.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016
Y1 - 2016
N2 - Suppression of band broadening in liquid chromatography is important to improve column efficiency. We investigate a mechanism of band broadening in the monodispersed and polydispersed microstructured-columns. The bed porosity and pillar size distribution were controlled in these columns by using microfabrication techniques. The decrease of the bed porosity increased the A term in the Knox plot. The polydispersed pillar columns decreased the B and C terms. These results suggested that the decrease of stagnation in microchannel caused the suppression of band broadening.
AB - Suppression of band broadening in liquid chromatography is important to improve column efficiency. We investigate a mechanism of band broadening in the monodispersed and polydispersed microstructured-columns. The bed porosity and pillar size distribution were controlled in these columns by using microfabrication techniques. The decrease of the bed porosity increased the A term in the Knox plot. The polydispersed pillar columns decreased the B and C terms. These results suggested that the decrease of stagnation in microchannel caused the suppression of band broadening.
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M3 - Conference contribution
AN - SCOPUS:85014267645
T3 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
SP - 1426
EP - 1427
BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PB - Chemical and Biological Microsystems Society
T2 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Y2 - 9 October 2016 through 13 October 2016
ER -