Successful treatment of pure red cell aplasia with cyclosporin A and erythropoietin after thymectomy in a 88-year old woman.

Toyoki Maeda; Satoshi Shiokawa; Yasuji Yoshikawa; Takashi Hiroyama; Yasuhiro Nakajima; Hiromi Muta; Masaharu Nakayama; Yukoh Nakazaki; Shinichiro Akizuki; Kanako Shimizu; Toshitaka Mutoh; Shinichi Somada; Ryo Kurita; Motoaki Shiratsuchi; Naoki Makino; Junji Nishimura; Kenzaburo Tani

Successful treatment of pure red cell aplasia with cyclosporin A and erythropoietin after thymectomy in a 88-year old woman.

Toyoki Maeda, Satoshi Shiokawa, Yasuji Yoshikawa, Takashi Hiroyama, Yasuhiro Nakajima, Hiromi Muta, Masaharu Nakayama, Yukoh Nakazaki, Shinichiro Akizuki, Kanako Shimizu, Toshitaka Mutoh, Shinichi Somada, Ryo Kurita, Motoaki Shiratsuchi, Naoki Makino, Junji Nishimura, Kenzaburo Tani

Internal Medicine

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

An 88-year old Japanese female with pure red cell aplasia was treated safely and effectively by a combination of thymectomy, cyclosporin A, and erythropoietin. The thymoma was histologically classified as lymphocytic type or cortical type, which are uncommon in cases of a thymoma accompanied by pure red cell aplasia. Immunohistochemical analysis of the thymoma and bone marrow revealed a predominance of CD8(+) cells. Thymectomy alone was ineffective, but cyclosporin A treatment subsequent to thymectomy was safe and effective and resulted in the disappearance of a Vbeta12 bearing T-cell clone in the bone marrow. Additional treatment with erythropoietin enhanced the effects of cyclosporin A and restored the patient's hemoglobin to normal levels. The beneficial effect of cyclosporin A may be attributed not to a broad immunomodulatory effect, but to a local effect on a limited T-cell subset.

Original language	English
Pages (from-to)	ECR17
Journal	Haematologica
Volume	89
Issue number	6 Suppl
Publication status	Published - Jun 2004

All Science Journal Classification (ASJC) codes

Hematology

Cite this

Maeda, T., Shiokawa, S., Yoshikawa, Y., Hiroyama, T., Nakajima, Y., Muta, H., Nakayama, M., Nakazaki, Y., Akizuki, S., Shimizu, K., Mutoh, T., Somada, S., Kurita, R., Shiratsuchi, M., Makino, N., Nishimura, J., & Tani, K. (2004). Successful treatment of pure red cell aplasia with cyclosporin A and erythropoietin after thymectomy in a 88-year old woman. Haematologica, 89(6 Suppl), ECR17.

Maeda, T, Shiokawa, S, Yoshikawa, Y, Hiroyama, T, Nakajima, Y, Muta, H, Nakayama, M, Nakazaki, Y, Akizuki, S, Shimizu, K, Mutoh, T, Somada, S, Kurita, R, Shiratsuchi, M, Makino, N, Nishimura, J & Tani, K 2004, 'Successful treatment of pure red cell aplasia with cyclosporin A and erythropoietin after thymectomy in a 88-year old woman.', Haematologica, vol. 89, no. 6 Suppl, pp. ECR17.

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title = "Successful treatment of pure red cell aplasia with cyclosporin A and erythropoietin after thymectomy in a 88-year old woman.",

abstract = "An 88-year old Japanese female with pure red cell aplasia was treated safely and effectively by a combination of thymectomy, cyclosporin A, and erythropoietin. The thymoma was histologically classified as lymphocytic type or cortical type, which are uncommon in cases of a thymoma accompanied by pure red cell aplasia. Immunohistochemical analysis of the thymoma and bone marrow revealed a predominance of CD8(+) cells. Thymectomy alone was ineffective, but cyclosporin A treatment subsequent to thymectomy was safe and effective and resulted in the disappearance of a Vbeta12 bearing T-cell clone in the bone marrow. Additional treatment with erythropoietin enhanced the effects of cyclosporin A and restored the patient's hemoglobin to normal levels. The beneficial effect of cyclosporin A may be attributed not to a broad immunomodulatory effect, but to a local effect on a limited T-cell subset.",

author = "Toyoki Maeda and Satoshi Shiokawa and Yasuji Yoshikawa and Takashi Hiroyama and Yasuhiro Nakajima and Hiromi Muta and Masaharu Nakayama and Yukoh Nakazaki and Shinichiro Akizuki and Kanako Shimizu and Toshitaka Mutoh and Shinichi Somada and Ryo Kurita and Motoaki Shiratsuchi and Naoki Makino and Junji Nishimura and Kenzaburo Tani",

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AU - Shiokawa, Satoshi

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AU - Hiroyama, Takashi

AU - Nakajima, Yasuhiro

AU - Muta, Hiromi

AU - Nakayama, Masaharu

AU - Nakazaki, Yukoh

AU - Akizuki, Shinichiro

AU - Shimizu, Kanako

AU - Mutoh, Toshitaka

AU - Somada, Shinichi

AU - Kurita, Ryo

AU - Shiratsuchi, Motoaki

AU - Makino, Naoki

AU - Nishimura, Junji

AU - Tani, Kenzaburo

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AB - An 88-year old Japanese female with pure red cell aplasia was treated safely and effectively by a combination of thymectomy, cyclosporin A, and erythropoietin. The thymoma was histologically classified as lymphocytic type or cortical type, which are uncommon in cases of a thymoma accompanied by pure red cell aplasia. Immunohistochemical analysis of the thymoma and bone marrow revealed a predominance of CD8(+) cells. Thymectomy alone was ineffective, but cyclosporin A treatment subsequent to thymectomy was safe and effective and resulted in the disappearance of a Vbeta12 bearing T-cell clone in the bone marrow. Additional treatment with erythropoietin enhanced the effects of cyclosporin A and restored the patient's hemoglobin to normal levels. The beneficial effect of cyclosporin A may be attributed not to a broad immunomodulatory effect, but to a local effect on a limited T-cell subset.

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Successful treatment of pure red cell aplasia with cyclosporin A and erythropoietin after thymectomy in a 88-year old woman.

Abstract

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