Successful treatment of progressive NK cell lymphoma with allogeneic peripheral stem cell transplantation followed by early cyclosporine tapering and donor leukocyte infusions

Masanori Makita; Yoshinobu Maeda; Katsuto Takenaka; Katsuji Shinagawa; Kazutaka Sunami; Yasushi Hiramatsu; Nobuharu Fujii; Fumihiko Ishimaru; Kazuma Ikeda; Kenji Niiya; Tadashi Yoshino; Mine Harada

doi:10.1007/BF02982726

Successful treatment of progressive NK cell lymphoma with allogeneic peripheral stem cell transplantation followed by early cyclosporine tapering and donor leukocyte infusions

Masanori Makita, Yoshinobu Maeda, Katsuto Takenaka, Katsuji Shinagawa, Kazutaka Sunami, Yasushi Hiramatsu, Nobuharu Fujii, Fumihiko Ishimaru, Kazuma Ikeda, Kenji Niiya, Tadashi Yoshino, Mine Harada

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

We describe a patient with progressive natural killer (NK) cell lymphoma who was treated successfully with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) followed by early cyclosporine (CsA) tapering and donor leukocyte infusion (DLI). Because the disease showed early resistance to conventional chemoradiotherapy, we performed high-dose chemotherapy followed by allo-PBSCT. After achieving hematologic engraftment, the patient underwent early tapering of CsA and DLI in an attempt to induce a graft-versus-lymphoma effect. Although the disease was in a progressive state at the time of transplantation, complete remission was obtained after allo-PBSCT. As of this report, the patient has been well for more than 2 years.

Original language	English
Pages (from-to)	94-97
Number of pages	4
Journal	International journal of hematology
Volume	76
Issue number	1
DOIs	https://doi.org/10.1007/BF02982726
Publication status	Published - Jul 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Hematology

Access to Document

10.1007/BF02982726

Cite this

Makita, M., Maeda, Y., Takenaka, K., Shinagawa, K., Sunami, K., Hiramatsu, Y., Fujii, N., Ishimaru, F., Ikeda, K., Niiya, K., Yoshino, T., & Harada, M. (2002). Successful treatment of progressive NK cell lymphoma with allogeneic peripheral stem cell transplantation followed by early cyclosporine tapering and donor leukocyte infusions. International journal of hematology, 76(1), 94-97. https://doi.org/10.1007/BF02982726

Successful treatment of progressive NK cell lymphoma with allogeneic peripheral stem cell transplantation followed by early cyclosporine tapering and donor leukocyte infusions. / Makita, Masanori; Maeda, Yoshinobu; Takenaka, Katsuto et al.
In: International journal of hematology, Vol. 76, No. 1, 07.2002, p. 94-97.

Research output: Contribution to journal › Article › peer-review

Makita, M, Maeda, Y, Takenaka, K, Shinagawa, K, Sunami, K, Hiramatsu, Y, Fujii, N, Ishimaru, F, Ikeda, K, Niiya, K, Yoshino, T & Harada, M 2002, 'Successful treatment of progressive NK cell lymphoma with allogeneic peripheral stem cell transplantation followed by early cyclosporine tapering and donor leukocyte infusions', International journal of hematology, vol. 76, no. 1, pp. 94-97. https://doi.org/10.1007/BF02982726

@article{3688baecbfe14121809fcc14195eb885,

title = "Successful treatment of progressive NK cell lymphoma with allogeneic peripheral stem cell transplantation followed by early cyclosporine tapering and donor leukocyte infusions",

abstract = "We describe a patient with progressive natural killer (NK) cell lymphoma who was treated successfully with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) followed by early cyclosporine (CsA) tapering and donor leukocyte infusion (DLI). Because the disease showed early resistance to conventional chemoradiotherapy, we performed high-dose chemotherapy followed by allo-PBSCT. After achieving hematologic engraftment, the patient underwent early tapering of CsA and DLI in an attempt to induce a graft-versus-lymphoma effect. Although the disease was in a progressive state at the time of transplantation, complete remission was obtained after allo-PBSCT. As of this report, the patient has been well for more than 2 years.",

author = "Masanori Makita and Yoshinobu Maeda and Katsuto Takenaka and Katsuji Shinagawa and Kazutaka Sunami and Yasushi Hiramatsu and Nobuharu Fujii and Fumihiko Ishimaru and Kazuma Ikeda and Kenji Niiya and Tadashi Yoshino and Mine Harada",

year = "2002",

month = jul,

doi = "10.1007/BF02982726",

language = "English",

volume = "76",

pages = "94--97",

journal = "International journal of hematology",

issn = "0925-5710",

publisher = "Springer Japan",

number = "1",

}

TY - JOUR

T1 - Successful treatment of progressive NK cell lymphoma with allogeneic peripheral stem cell transplantation followed by early cyclosporine tapering and donor leukocyte infusions

AU - Makita, Masanori

AU - Maeda, Yoshinobu

AU - Takenaka, Katsuto

AU - Shinagawa, Katsuji

AU - Sunami, Kazutaka

AU - Hiramatsu, Yasushi

AU - Fujii, Nobuharu

AU - Ishimaru, Fumihiko

AU - Ikeda, Kazuma

AU - Niiya, Kenji

AU - Yoshino, Tadashi

AU - Harada, Mine

PY - 2002/7

Y1 - 2002/7

N2 - We describe a patient with progressive natural killer (NK) cell lymphoma who was treated successfully with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) followed by early cyclosporine (CsA) tapering and donor leukocyte infusion (DLI). Because the disease showed early resistance to conventional chemoradiotherapy, we performed high-dose chemotherapy followed by allo-PBSCT. After achieving hematologic engraftment, the patient underwent early tapering of CsA and DLI in an attempt to induce a graft-versus-lymphoma effect. Although the disease was in a progressive state at the time of transplantation, complete remission was obtained after allo-PBSCT. As of this report, the patient has been well for more than 2 years.

AB - We describe a patient with progressive natural killer (NK) cell lymphoma who was treated successfully with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) followed by early cyclosporine (CsA) tapering and donor leukocyte infusion (DLI). Because the disease showed early resistance to conventional chemoradiotherapy, we performed high-dose chemotherapy followed by allo-PBSCT. After achieving hematologic engraftment, the patient underwent early tapering of CsA and DLI in an attempt to induce a graft-versus-lymphoma effect. Although the disease was in a progressive state at the time of transplantation, complete remission was obtained after allo-PBSCT. As of this report, the patient has been well for more than 2 years.

UR - http://www.scopus.com/inward/record.url?scp=17144473414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17144473414&partnerID=8YFLogxK

U2 - 10.1007/BF02982726

DO - 10.1007/BF02982726

M3 - Article

C2 - 12138904

AN - SCOPUS:17144473414

SN - 0925-5710

VL - 76

SP - 94

EP - 97

JO - International journal of hematology

JF - International journal of hematology

IS - 1

ER -

Successful treatment of progressive NK cell lymphoma with allogeneic peripheral stem cell transplantation followed by early cyclosporine tapering and donor leukocyte infusions

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this