Successful treatment of lupus cerebrovascular disease with mycophenolate mofetil

Kazuhiko Higashioka; Kenji Yoshida; Kensuke Oryoji; Kazuo Kamada; Shinichi Mizuki; Hiroshi Tsukamoto; Eisuke Yokota; Koichi Akashi

doi:10.2169/internalmedicine.54.4582

Successful treatment of lupus cerebrovascular disease with mycophenolate mofetil

Kazuhiko Higashioka, Kenji Yoshida, Kensuke Oryoji, Kazuo Kamada, Shinichi Mizuki, Hiroshi Tsukamoto, Eisuke Yokota, Koichi Akashi

Internal Medicine

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We report a case of neuropsychiatric systemic lupus erythematosus successfully treated with mycophenolate mofetil (MMF). The patient was a 40-year-old female who maintained with 7 mg of prednisolone plus 100 mg of azathioprine (AZ) per day. According to transient ischemic attack that occurred repeatedly and an elevated level of interleukin-6 (IL-6) in spinal fluid, she was diagnosed as having neuropsychiatric systemic lupus erythematosus (NPSLE). Initial increase in doses of prednisolone and AZ to 20 mg and 150 mg per day, respectively, was ineffective. After switching from AZ to MMF, her symptoms of NPSLE completely resolved with marked improvement of the IL-6 level in her spinal fluid, suggesting that MMF was effective.

Original language	English
Pages (from-to)	2255-2259
Number of pages	5
Journal	Internal Medicine
Volume	54
Issue number	17
DOIs	https://doi.org/10.2169/internalmedicine.54.4582
Publication status	Published - Sept 1 2015

All Science Journal Classification (ASJC) codes

Internal Medicine

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10.2169/internalmedicine.54.4582

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title = "Successful treatment of lupus cerebrovascular disease with mycophenolate mofetil",

abstract = "We report a case of neuropsychiatric systemic lupus erythematosus successfully treated with mycophenolate mofetil (MMF). The patient was a 40-year-old female who maintained with 7 mg of prednisolone plus 100 mg of azathioprine (AZ) per day. According to transient ischemic attack that occurred repeatedly and an elevated level of interleukin-6 (IL-6) in spinal fluid, she was diagnosed as having neuropsychiatric systemic lupus erythematosus (NPSLE). Initial increase in doses of prednisolone and AZ to 20 mg and 150 mg per day, respectively, was ineffective. After switching from AZ to MMF, her symptoms of NPSLE completely resolved with marked improvement of the IL-6 level in her spinal fluid, suggesting that MMF was effective.",

author = "Kazuhiko Higashioka and Kenji Yoshida and Kensuke Oryoji and Kazuo Kamada and Shinichi Mizuki and Hiroshi Tsukamoto and Eisuke Yokota and Koichi Akashi",

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T1 - Successful treatment of lupus cerebrovascular disease with mycophenolate mofetil

AU - Higashioka, Kazuhiko

AU - Yoshida, Kenji

AU - Oryoji, Kensuke

AU - Kamada, Kazuo

AU - Mizuki, Shinichi

AU - Tsukamoto, Hiroshi

AU - Yokota, Eisuke

AU - Akashi, Koichi

PY - 2015/9/1

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N2 - We report a case of neuropsychiatric systemic lupus erythematosus successfully treated with mycophenolate mofetil (MMF). The patient was a 40-year-old female who maintained with 7 mg of prednisolone plus 100 mg of azathioprine (AZ) per day. According to transient ischemic attack that occurred repeatedly and an elevated level of interleukin-6 (IL-6) in spinal fluid, she was diagnosed as having neuropsychiatric systemic lupus erythematosus (NPSLE). Initial increase in doses of prednisolone and AZ to 20 mg and 150 mg per day, respectively, was ineffective. After switching from AZ to MMF, her symptoms of NPSLE completely resolved with marked improvement of the IL-6 level in her spinal fluid, suggesting that MMF was effective.

AB - We report a case of neuropsychiatric systemic lupus erythematosus successfully treated with mycophenolate mofetil (MMF). The patient was a 40-year-old female who maintained with 7 mg of prednisolone plus 100 mg of azathioprine (AZ) per day. According to transient ischemic attack that occurred repeatedly and an elevated level of interleukin-6 (IL-6) in spinal fluid, she was diagnosed as having neuropsychiatric systemic lupus erythematosus (NPSLE). Initial increase in doses of prednisolone and AZ to 20 mg and 150 mg per day, respectively, was ineffective. After switching from AZ to MMF, her symptoms of NPSLE completely resolved with marked improvement of the IL-6 level in her spinal fluid, suggesting that MMF was effective.

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Successful treatment of lupus cerebrovascular disease with mycophenolate mofetil

Abstract

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