Successful surgical treatment for pulmonary crystal-storing histiocytosis following the onset of gastric non-hodgkin lymphoma.

Noriaki Kawano, Kiichiro Beppu, Mayumi Oyama, Daisuke Himeji, Shuro Yoshida, Takuro Kuriyama, Nobuyuki Ono, Hiroyuki Masuyama, Kiyoshi Yamashita, Kenichiro Yamaguchi, Yoshiya Shimao, Koichi Oshima, Yuji Ueda, Akira Ueda

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Crystal-storing histiocytosis is a rare clinical entity characterized by an increase in the number of abnormal histiocytes accompanied by accumulation of crystallized immunoglobulins. We describe the case of an 80-year-old man who presented with crystal-storing histiocytosis of the lung 13 years after receiving a diagnosis of gastric non-Hodgkin lymphoma (NHL ; clinical stage, Lugano IA). After wedge resection of the left upper lobe, the histological findings showed crystal-storing histiocytosis with CD68(+), some small to medium lymphoid cells with CD79a(+) with κ(+(weekly)) and λ(-), and some plasma cells with CD138(+), and rearrangement of the immunoglobulin heavy chain. Based on the nonrecurrent gastric NHL, small B-cell population, and failure to detect the same clone by polymerase chain reaction analysis, our case was classified as pulmonary localized crystal-storing histiocytosis without underlying lymphoproliferative or plasma cell disorder. The findings of minor B-cell populations harboring a heavy chain rearrangement with slight light-chain restriction (κ > λ) may be related to the pathogenesis of crystallogenesis and crystal-storing histiocytosis. Moreover, surgical treatment may be an effective therapeutic option for solitary crystal-storing histiocytosis.

Original languageEnglish
Pages (from-to)241-245
Number of pages5
JournalJournal of clinical and experimental hematopathology : JCEH
Issue number3
Publication statusPublished - 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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