Abstract
We propose the application of spectroscopy-tomography to single cells to improve the early detection and treatment of cancer. This technology can obtain the 3-dimensional distribution of components at a high spatial resolution. In this paper, we discuss the analytical results of cross-sectional imaging of a microsphere 10 μm in diameter. The distribution of the internal submicron-sized defect in the microsphere could be analyzed. To correct the center of rotation, we propose image processing using a normalized correlation function as an estimation value. The cross-sectional image of the microsphere was improved and the vague internal defect becames more clearly distinguishable by this proposed method. We also discuss variable phase-contrast spectrometry as our proposed 2-dimensional high-spatial-resolution spectrometry. This method is a phase-shift interferometry between 0th-order diffracted light and higher-order diffracted light. We discuss the experimental results of spectra derived from this method. We measured the spectral characteristics at each pixel using a color filter for liquid crystal and verified that the 2-dimensional spectral characteristics can be measured with good results.
| Original language | English |
|---|---|
| Pages | 3762-3766 |
| Number of pages | 5 |
| Publication status | Published - 2005 |
| Externally published | Yes |
| Event | SICE Annual Conference 2005 - Okayama, Japan Duration: Aug 8 2005 → Aug 10 2005 |
Other
| Other | SICE Annual Conference 2005 |
|---|---|
| Country/Territory | Japan |
| City | Okayama |
| Period | 8/8/05 → 8/10/05 |
All Science Journal Classification (ASJC) codes
- Control and Systems Engineering
- Computer Science Applications
- Electrical and Electronic Engineering
