Structure of a novel multidrug resistance modulator, irciniasulfonic acid, isolated from a marine sponge, Ircinia sp.

Ayako Kawakami; Tomofumi Miyamoto; Ryuichi Higuchi; Takeshi Uchiumi; Michihiko Kuwano; Rob W.M. Van Soest

doi:10.1016/S0040-4039(01)00426-9

Structure of a novel multidrug resistance modulator, irciniasulfonic acid, isolated from a marine sponge, Ircinia sp.

Ayako Kawakami, Tomofumi Miyamoto, Ryuichi Higuchi, Takeshi Uchiumi, Michihiko Kuwano, Rob W.M. Van Soest

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Irciniasulfonic acid was obtained from a marine sponge of Ircinia sp. Spectroscopic and chemical analyses revealed its structure consists of three different kinds of acids, i.e. common fatty acids, a novel unsaturated branched C-10 fatty acid and an isethionic acid. Irciniasulfonic acid and deacyl irciniasulfonic acid reverse multidrug resistance in human carcinoma cells caused by overexpression of membrane glycoprotein.

Original language	English
Pages (from-to)	3335-3337
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	19
DOIs	https://doi.org/10.1016/S0040-4039(01)00426-9
Publication status	Published - May 7 2001

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)00426-9

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title = "Structure of a novel multidrug resistance modulator, irciniasulfonic acid, isolated from a marine sponge, Ircinia sp.",

abstract = "Irciniasulfonic acid was obtained from a marine sponge of Ircinia sp. Spectroscopic and chemical analyses revealed its structure consists of three different kinds of acids, i.e. common fatty acids, a novel unsaturated branched C-10 fatty acid and an isethionic acid. Irciniasulfonic acid and deacyl irciniasulfonic acid reverse multidrug resistance in human carcinoma cells caused by overexpression of membrane glycoprotein.",

author = "Ayako Kawakami and Tomofumi Miyamoto and Ryuichi Higuchi and Takeshi Uchiumi and Michihiko Kuwano and {Van Soest}, {Rob W.M.}",

note = "Funding Information: We would like to thank Professor T. Murae of the Graduate School of Science, Kyushu University for providing HR-API-TOFMS data. This work was supported in part by a Scientific Research Grant (No. 12672055) from The Ministry of Education, Science, Sports and Culture, Japan.",

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T1 - Structure of a novel multidrug resistance modulator, irciniasulfonic acid, isolated from a marine sponge, Ircinia sp.

AU - Kawakami, Ayako

AU - Miyamoto, Tomofumi

AU - Higuchi, Ryuichi

AU - Uchiumi, Takeshi

AU - Kuwano, Michihiko

AU - Van Soest, Rob W.M.

N1 - Funding Information: We would like to thank Professor T. Murae of the Graduate School of Science, Kyushu University for providing HR-API-TOFMS data. This work was supported in part by a Scientific Research Grant (No. 12672055) from The Ministry of Education, Science, Sports and Culture, Japan.

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N2 - Irciniasulfonic acid was obtained from a marine sponge of Ircinia sp. Spectroscopic and chemical analyses revealed its structure consists of three different kinds of acids, i.e. common fatty acids, a novel unsaturated branched C-10 fatty acid and an isethionic acid. Irciniasulfonic acid and deacyl irciniasulfonic acid reverse multidrug resistance in human carcinoma cells caused by overexpression of membrane glycoprotein.

AB - Irciniasulfonic acid was obtained from a marine sponge of Ircinia sp. Spectroscopic and chemical analyses revealed its structure consists of three different kinds of acids, i.e. common fatty acids, a novel unsaturated branched C-10 fatty acid and an isethionic acid. Irciniasulfonic acid and deacyl irciniasulfonic acid reverse multidrug resistance in human carcinoma cells caused by overexpression of membrane glycoprotein.

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Structure of a novel multidrug resistance modulator, irciniasulfonic acid, isolated from a marine sponge, Ircinia sp.

Abstract

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