Structure-activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum

Jie Liu; Kenji Kurashiki; Kuniyoshi Shimizu; Ryuichiro Kondo

doi:10.1016/j.bmc.2006.08.018

Structure-activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum

Jie Liu, Kenji Kurashiki, Kuniyoshi Shimizu, Ryuichiro Kondo

Sustainable Bioresources Science

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Abstract

In humans, 5α-reductase is involved in the development of benign prostatic hyperplasia. Triterpenoids isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) inhibited 5α-reductase activity. The presence of the C-3 carbonyl group and of the C-26-α,β-unsaturated carbonyl group was characteristic of almost all inhibitors isolated from G. lucidum.

Original language	English
Pages (from-to)	8654-8660
Number of pages	7
Journal	Bioorganic and Medicinal Chemistry
Volume	14
Issue number	24
DOIs	https://doi.org/10.1016/j.bmc.2006.08.018
Publication status	Published - Dec 15 2006

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2006.08.018

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abstract = "In humans, 5α-reductase is involved in the development of benign prostatic hyperplasia. Triterpenoids isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) inhibited 5α-reductase activity. The presence of the C-3 carbonyl group and of the C-26-α,β-unsaturated carbonyl group was characteristic of almost all inhibitors isolated from G. lucidum.",

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AU - Kondo, Ryuichiro

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AB - In humans, 5α-reductase is involved in the development of benign prostatic hyperplasia. Triterpenoids isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) inhibited 5α-reductase activity. The presence of the C-3 carbonyl group and of the C-26-α,β-unsaturated carbonyl group was characteristic of almost all inhibitors isolated from G. lucidum.

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ER -

Structure-activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum

Abstract

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