Structural Elucidation of Minor Components of Peptidyl Antibiotic P168s (Leucinostatins) by Tandem Mass Spectrometry

Akira Isogai, Jiro Nakayama, Seiji Takayama, Akinori Suzuki, Akihiko Kusai

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Tandem mass spectrometry with a four-sector type mass spectrometer was used to elucidate the structures of minor components of the peptidyl antibiotic P168s (leucinostatins). As N-terminal fragments, ions by B-type cleavage were dominant, while V-type cleavages were observed along with X, Y, and Z types as C-terminal ions. The V-type ions were predominant in the cleavages of the amino terminals of leucyl and hydroxyleucyl residues. The structures of several minor components could be deduced from the tandem mass spectra.

Original languageEnglish
Pages (from-to)1079-1085
Number of pages7
JournalBioscience, biotechnology, and biochemistry
Volume56
Issue number7
DOIs
Publication statusPublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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