Structural analysis by NMR of antitumor drug-DNA complexes: 9-aminoanthracycline (SM-5887)

Jun etsu Igarashi; Makoto Sunagawa

doi:10.1016/0960-894X(95)00505-N

Structural analysis by NMR of antitumor drug-DNA complexes: 9-aminoanthracycline (SM-5887)

Jun etsu Igarashi, Makoto Sunagawa

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

SM-5887 is an anthracycline antibiotic with a potent antitumor activity and low toxicity. The structure of the 2:1 SM-5887 -d(CGTACG) complex has been studied in solution by 2D NMR spectroscopy. These data revealed that SM-5887 intercalated between the cytosine and guanine residues and the sugar moiety lay in the minor groove. The intercalation geometry of SM-5887 was a hybrid between those of adriamycin and nogalamycin.

Original language	English
Pages (from-to)	2923-2928
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	23
DOIs	https://doi.org/10.1016/0960-894X(95)00505-N
Publication status	Published - Dec 7 1995
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/0960-894X(95)00505-N

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abstract = "SM-5887 is an anthracycline antibiotic with a potent antitumor activity and low toxicity. The structure of the 2:1 SM-5887 -d(CGTACG) complex has been studied in solution by 2D NMR spectroscopy. These data revealed that SM-5887 intercalated between the cytosine and guanine residues and the sugar moiety lay in the minor groove. The intercalation geometry of SM-5887 was a hybrid between those of adriamycin and nogalamycin.",

author = "Igarashi, {Jun etsu} and Makoto Sunagawa",

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AU - Igarashi, Jun etsu

AU - Sunagawa, Makoto

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Y1 - 1995/12/7

N2 - SM-5887 is an anthracycline antibiotic with a potent antitumor activity and low toxicity. The structure of the 2:1 SM-5887 -d(CGTACG) complex has been studied in solution by 2D NMR spectroscopy. These data revealed that SM-5887 intercalated between the cytosine and guanine residues and the sugar moiety lay in the minor groove. The intercalation geometry of SM-5887 was a hybrid between those of adriamycin and nogalamycin.

AB - SM-5887 is an anthracycline antibiotic with a potent antitumor activity and low toxicity. The structure of the 2:1 SM-5887 -d(CGTACG) complex has been studied in solution by 2D NMR spectroscopy. These data revealed that SM-5887 intercalated between the cytosine and guanine residues and the sugar moiety lay in the minor groove. The intercalation geometry of SM-5887 was a hybrid between those of adriamycin and nogalamycin.

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JF - Bioorganic and Medicinal Chemistry Letters

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ER -

Structural analysis by NMR of antitumor drug-DNA complexes: 9-aminoanthracycline (SM-5887)

Abstract

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