TY - JOUR
T1 - Streptococcus pyogenes-purpura fulminans as an invasive form of group A streptococcal infection
AU - Kawaguchi, Sayaka
AU - Ishimura, Masataka
AU - Kanno, Shunsuke
AU - Sonoda, Motoshi
AU - Kaku, Noriyuki
AU - Motomura, Yoshitomo
AU - Nishio, Hisanori
AU - Oba, Utako
AU - Hanada, Masuo
AU - Fukushi, Jun-Ichi
AU - Urata, Michiyo
AU - Kang, Dongchon
AU - Takada, Hidetoshi
AU - Ohga, Shouichi
N1 - Funding Information:
This work was supported by Practical Research Project for Rare/Intractable Diseases (JP17ek0109260, JP18ek0109260) and Grant‑in‑Aids (S.O. 15545383, 15545623) from the Japan Agency for Medical Research and Development (AMED) and the Research on Measures for Intractable Diseases Project and Health and Labor Sciences Research grants (Research on Intractable Diseases) from the Ministry of Health, Labour and Welfare.
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/7/9
Y1 - 2018/7/9
N2 - Background: Streptococcus pyogenes is an uncommon pathogen of purpura fulminans, and the pathogenesis of S. pyogenes-purpura fulminans remains unclear because of paucity of cases. We reported a pediatric case of S. pyogenes-purpura fulminans with literature review of the disease. Case presentation: A 3-year-old boy showed limping, lethargy and acral gangrene within 24 h. A diagnosis of S. pyogenes-purpura fulminans was made for bacterial isolation from throat and peripheral blood. Intensive therapy led to a survival with amputation of the left distal metatarsal bone, and normal development. The isolated M12 carried no mutation of csrS/R or rgg. Thrombophilia or immunodeficiency was excluded. Discussion: Twelve-reported cases (9 pediatric and 3 elderly) of S. pyogenes-purpura fulminans started with shock and coagulopathy. Five patients age < 8 years had no underlying disease and survived. One youngest and two immunocompromised patients died. Conclusion:Streptococcus pyogenes-acute infectious purpura fulminans is a distinctive rare form of aggressive GAS infections.
AB - Background: Streptococcus pyogenes is an uncommon pathogen of purpura fulminans, and the pathogenesis of S. pyogenes-purpura fulminans remains unclear because of paucity of cases. We reported a pediatric case of S. pyogenes-purpura fulminans with literature review of the disease. Case presentation: A 3-year-old boy showed limping, lethargy and acral gangrene within 24 h. A diagnosis of S. pyogenes-purpura fulminans was made for bacterial isolation from throat and peripheral blood. Intensive therapy led to a survival with amputation of the left distal metatarsal bone, and normal development. The isolated M12 carried no mutation of csrS/R or rgg. Thrombophilia or immunodeficiency was excluded. Discussion: Twelve-reported cases (9 pediatric and 3 elderly) of S. pyogenes-purpura fulminans started with shock and coagulopathy. Five patients age < 8 years had no underlying disease and survived. One youngest and two immunocompromised patients died. Conclusion:Streptococcus pyogenes-acute infectious purpura fulminans is a distinctive rare form of aggressive GAS infections.
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U2 - 10.1186/s12941-018-0282-9
DO - 10.1186/s12941-018-0282-9
M3 - Article
C2 - 29986727
AN - SCOPUS:85049795102
SN - 1476-0711
VL - 17
JO - Annals of Clinical Microbiology and Antimicrobials
JF - Annals of Clinical Microbiology and Antimicrobials
IS - 1
M1 - 31
ER -
