Stimuli-responsive liposome aggregation induced by DNA-surfactants

Tatsuo Maruyama; Mai Hiraki; Hiroshi Yamamura; Harumi Takata; Masahiro Goto

Stimuli-responsive liposome aggregation induced by DNA-surfactants

Tatsuo Maruyama, Mai Hiraki, Hiroshi Yamamura, Harumi Takata, Masahiro Goto

Research output: Contribution to conference › Paper › peer-review

Abstract

Here we describe a novel strategy of liposome aggregation employing DNA-surfactant, in which the aggregation of liposomes can be reversibly controlled by enzyme stimuli and temperature. Single-stranded oligonucleotides (24-mer) were bound to oleic acid to produce DNA-surfactant. The DNA surfactant was mixed with POPC liposomes to prepare DNA-tethered liposomes. Mixing of the DNA-tagged liposomes with ones bearing complementary DNA strands starts the aggregation of liposomes. The liposomes were linked with each other via duplex DNA. We found that the liposome aggregation was influenced by temperature, salt concentration and restriction enzyme.

Original language	English
Pages	3873-3874
Number of pages	2
Publication status	Published - 2005
Event	54th SPSJ Symposium on Macromolecules - Yamagata, Japan Duration: Sept 20 2005 → Sept 22 2005

Other

Other	54th SPSJ Symposium on Macromolecules
Country/Territory	Japan
City	Yamagata
Period	9/20/05 → 9/22/05

All Science Journal Classification (ASJC) codes

Engineering(all)

Cite this

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title = "Stimuli-responsive liposome aggregation induced by DNA-surfactants",

abstract = "Here we describe a novel strategy of liposome aggregation employing DNA-surfactant, in which the aggregation of liposomes can be reversibly controlled by enzyme stimuli and temperature. Single-stranded oligonucleotides (24-mer) were bound to oleic acid to produce DNA-surfactant. The DNA surfactant was mixed with POPC liposomes to prepare DNA-tethered liposomes. Mixing of the DNA-tagged liposomes with ones bearing complementary DNA strands starts the aggregation of liposomes. The liposomes were linked with each other via duplex DNA. We found that the liposome aggregation was influenced by temperature, salt concentration and restriction enzyme.",

author = "Tatsuo Maruyama and Mai Hiraki and Hiroshi Yamamura and Harumi Takata and Masahiro Goto",

year = "2005",

language = "English",

pages = "3873--3874",

note = "54th SPSJ Symposium on Macromolecules ; Conference date: 20-09-2005 Through 22-09-2005",

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TY - CONF

T1 - Stimuli-responsive liposome aggregation induced by DNA-surfactants

AU - Maruyama, Tatsuo

AU - Hiraki, Mai

AU - Yamamura, Hiroshi

AU - Takata, Harumi

AU - Goto, Masahiro

PY - 2005

Y1 - 2005

N2 - Here we describe a novel strategy of liposome aggregation employing DNA-surfactant, in which the aggregation of liposomes can be reversibly controlled by enzyme stimuli and temperature. Single-stranded oligonucleotides (24-mer) were bound to oleic acid to produce DNA-surfactant. The DNA surfactant was mixed with POPC liposomes to prepare DNA-tethered liposomes. Mixing of the DNA-tagged liposomes with ones bearing complementary DNA strands starts the aggregation of liposomes. The liposomes were linked with each other via duplex DNA. We found that the liposome aggregation was influenced by temperature, salt concentration and restriction enzyme.

AB - Here we describe a novel strategy of liposome aggregation employing DNA-surfactant, in which the aggregation of liposomes can be reversibly controlled by enzyme stimuli and temperature. Single-stranded oligonucleotides (24-mer) were bound to oleic acid to produce DNA-surfactant. The DNA surfactant was mixed with POPC liposomes to prepare DNA-tethered liposomes. Mixing of the DNA-tagged liposomes with ones bearing complementary DNA strands starts the aggregation of liposomes. The liposomes were linked with each other via duplex DNA. We found that the liposome aggregation was influenced by temperature, salt concentration and restriction enzyme.

UR - http://www.scopus.com/inward/record.url?scp=33645582761&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645582761&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645582761

SP - 3873

EP - 3874

T2 - 54th SPSJ Symposium on Macromolecules

Y2 - 20 September 2005 through 22 September 2005

ER -

Stimuli-responsive liposome aggregation induced by DNA-surfactants

Abstract

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