@article{a88c4c8eec724b65b1118a1f3201d3bb,
title = "Stereospecific Overman Rearrangement of Substituted Cyclic Vinyl Bromides: Access to Fully Substituted α-Amino Ketones",
abstract = "A versatile thermal Overman rearrangement of enantioenriched, cyclic allylic alcohols providing tertiary allylic amines has been developed. The vinyl bromide used to control enantioselectivity in a preceding CBS reduction is utilized as a synthetic handle for the preparation of tertiary α-amino ketones and related derivatives in an asymmetric fashion.",
author = "{\'A}lvaro Velasco-Rubio and Alexy, {Eric J.} and Makoto Yoritate and Wright, {Austin C.} and Stoltz, {Brian M.}",
note = "Funding Information: We thank NIH-NIGMS (R01GM080269) and Caltech for financial support. A.V.-R. thanks Xunta de Galicia for a predoctoral fellowship (ED481A-2018/34, 2018-2021). E.J.A. thanks the National Science Foundation for a predoctoral fellowship. We thank Dr. David VanderVelde (Caltech) for NMR expertise. Larry Henling (Caltech) and Dr. Michael Takase (Caltech) are thanked for X-ray crystallographic structure determination. Dr. Scott Virgil (Caltech) is thanked for instrumentation and SFC assistance Funding Information: We thank NIH-NIGMS (R01GM080269) and Caltech for financial support. A.V.-R. thanks Xunta de Galicia for a predoctoral fellowship (ED481A-2018/34, 2018-2021). E.J.A. thanks the National Science Foundation for a predoctoral fellowship. We thank Dr. David VanderVelde (Caltech) for NMR expertise. Larry Henling (Caltech) and Dr. Michael Takase (Caltech) are thanked for X-ray crystallographic structure determination. Dr. Scott Virgil (Caltech) is thanked for instrumentation and SFC assistance. Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",
year = "2019",
month = nov,
day = "15",
doi = "10.1021/acs.orglett.9b03347",
language = "English",
volume = "21",
pages = "8962--8965",
journal = "Organic letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "22",
}