Stereoselective Synthesis of C -Aryl-α-Glycosides by Reductive C(sp2)-C(sp3) Cross-Coupling Reaction

Noyuri Kudo, Suzuka Chiba, Shunsuke Ono, Masataka Nagatoishi, Makoto Yoritate, Satoru Karasawa, Kazuteru Usui, Go Hirai

Research output: Contribution to journalArticlepeer-review

Abstract

C -aryl glycosides have attracted considerable interest as biologically active natural products and as O -aryl glycoside mimetics in drug discovery. Here, we describe a straightforward synthesis of C -aryl glycosides via photoredox/Ni dual-catalyzed reductive cross-coupling between glycosyl bromides and aryl bromides. This methodology enables highly α-stereoselective synthesis of C -aryl-glucosides, galactosides, and mannosides.

Original languageEnglish
JournalSynlett
DOIs
Publication statusAccepted/In press - 2024

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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