TY - JOUR
T1 - Stereodivergent direct catalytic asymmetric mannich-type reactions of α-isothiocyanato ester with ketimines
AU - Lu, Gang
AU - Yoshino, Tatsuhiko
AU - Morimoto, Hiroyuki
AU - Matsunaga, Shigeki
AU - Shibasaki, Masakatsu
PY - 2011/5/2
Y1 - 2011/5/2
N2 - Now accessible: Sterically hindered vicinal tetrasubstituted carbon stereocenters, which are not accessible by asymmetric hydrogenation, were constructed by a catalytic asymmetric C-C bond formation (see scheme; Dpp=diphenylphosphinoyl). By changing the Group 2 metal center, stereodivergent access to α,β-tetrasubstituted α,β-diamino esters was realized.
AB - Now accessible: Sterically hindered vicinal tetrasubstituted carbon stereocenters, which are not accessible by asymmetric hydrogenation, were constructed by a catalytic asymmetric C-C bond formation (see scheme; Dpp=diphenylphosphinoyl). By changing the Group 2 metal center, stereodivergent access to α,β-tetrasubstituted α,β-diamino esters was realized.
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U2 - 10.1002/anie.201101034
DO - 10.1002/anie.201101034
M3 - Article
C2 - 21484977
AN - SCOPUS:79955494420
SN - 1433-7851
VL - 50
SP - 4382
EP - 4385
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 19
ER -