Statin and BMP

Keizo Ohnaka, Ryoichi Takayanagi

Research output: Contribution to journalReview articlepeer-review


Bone morphogenetic proteins (BMP) are cytokines that promote differentiation of mesenchymal stem cells into differentiated osteoblasts and bone formation. Recently, HMG-CoA reductase inhibitors (statins) emerged as a candidate for the treatment of osteoporosis, because they stimulate BMP-2 expression and bone formation. Inhibition of Rho/Rho-kinase pathway may be involved in statin effect on bone formation.

Original languageEnglish
Pages (from-to)286-288
Number of pages3
JournalClinical calcium
Issue number2
Publication statusPublished - Feb 2004

All Science Journal Classification (ASJC) codes

  • General Medicine


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