Stage I and II non-Hodgkin's lymphoma: Results of combined of THP-COP chemotherapy and radiotherapy

Saiji Ohga, Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Yusuke Urashima, Hiromi Terashima, Hiroshi Honda

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    3 Citations (Scopus)


    Purpose: We evaluated the usefulness of radiotherapy plus THP-COP chemotherapy consisting of cyclophosphamide, vincristine, pirarubicin (tetrahydropyranyl adriamycin, THP), and prednisone for stage I and II non-Hodgkin's lymphoma (NHL). Patients and Methods: Between October 1998 and October 2001, 32 patients with Stage I or II NHL were treated with THP-COP plus radiotherapy. The patients consisted of 19 men and 13 women with a median age of 60 years (range, 23-81 years). The histological type was intermediate grade in 29, high in one, and unclassified in two. The number of cycles of THP-COP ranged from three to six (median, three cycles). Doses of irradiation ranged from 18.0 to 46.5 Gy (median, 40.0 Gy). The median length of follow-up was 19 months (range, 1-47 months). Results: The 3-year overall survival rate and progression-free survival rate were 81.3% and 74.9%, respectively. Leukopenia of grade 3-4 was documented in 24 patients (75%) and thrombopenia of grade 3-4 in four (12.5%). Conclusion: THP-COP plus radiotherapy appeared to be feasible for stage I and II NHL patients. However, further evaluation is needed to determine the usefulness of this treatment.

    Original languageEnglish
    Pages (from-to)156-161
    Number of pages6
    JournalRadiation Medicine - Medical Imaging and Radiation Oncology
    Issue number3
    Publication statusPublished - May 2005

    All Science Journal Classification (ASJC) codes

    • Radiation
    • Radiology Nuclear Medicine and imaging
    • Oncology


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