TY - GEN
T1 - Stable cellular force measurement by on-chip robotic probe by employing surface-directed liquid flow
AU - Sakuma, S.
AU - Sugita, M.
AU - Arai, F.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - This paper presents a novel on-chip manipulation method of a single cell using a surface-directed liquid flow. In order to avoid the oscillation disturbance due to the motion of on-chip robotic probe, air-liquid interface separated the driving point from the on-chip probe, and only manipulation point approached cell in the microchannel. The surface-directed liquid flow was formed by the nanopillar micropatterns fabricated by the multi-scale patterning technique. Wide range wettability control of the substrate was achieved by changing the density of nanopillars to obtain the robust air-liquid interface. The oscillation of microparticles was dramatically reduced by the surface-directed liquid flow. Finally, the cellular force measurement, which required the stable cell manipulation, was achieved.
AB - This paper presents a novel on-chip manipulation method of a single cell using a surface-directed liquid flow. In order to avoid the oscillation disturbance due to the motion of on-chip robotic probe, air-liquid interface separated the driving point from the on-chip probe, and only manipulation point approached cell in the microchannel. The surface-directed liquid flow was formed by the nanopillar micropatterns fabricated by the multi-scale patterning technique. Wide range wettability control of the substrate was achieved by changing the density of nanopillars to obtain the robust air-liquid interface. The oscillation of microparticles was dramatically reduced by the surface-directed liquid flow. Finally, the cellular force measurement, which required the stable cell manipulation, was achieved.
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U2 - 10.1109/Transducers.2013.6627243
DO - 10.1109/Transducers.2013.6627243
M3 - Conference contribution
AN - SCOPUS:84891714142
SN - 9781467359818
T3 - 2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
SP - 2213
EP - 2216
BT - 2013 Transducers and Eurosensors XXVII
T2 - 2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
Y2 - 16 June 2013 through 20 June 2013
ER -