TY - JOUR
T1 - Squamous cell carcinoma arising in sacrococcygeal teratoma in an adult
T2 - A case report
AU - Tanaka, Yasushi
AU - Nakanishi, Ryota
AU - Hazama, Hirokuni
AU - Mori, Taro
AU - Kawazoe, Tetsuro
AU - Kudou, Kensuke
AU - Zaitsu, Yoko
AU - Hisamatsu, Yuichi
AU - Ando, Koji
AU - Oki, Eiji
AU - Aishima, Shinichi
AU - Oda, Yoshinao
AU - Yoshizumi, Tomoharu
N1 - Publisher Copyright:
© 2025 The Author(s)
PY - 2025/6
Y1 - 2025/6
N2 - Sacrococcygeal teratomas (SCT) with malignant transformation to squamous cell carcinoma are extremely rare, with only few cases reported in the literature. Herein, we report on a case of a primary sacrococcygeal mature cystic teratoma with malignant transformation into a squamous cell carcinoma. A 53-year-old woman presented with dysuria and lower abdominal pain caused by a huge SCT. Computed tomography (CT), magnetic resonance imaging, and positron emission tomography/CT findings were suggestive of SCT with malignant transformation. The treatment involved robotic-assisted laparoscopic abdominoperineal resection and bilateral lymph node dissection. Histopathology revealed squamous cell carcinoma within the teratoma. Postoperatively, the patient underwent six cycles of paclitaxel-carboplatin chemotherapy and showed no signs of recurrence during the 1-year follow-up.
AB - Sacrococcygeal teratomas (SCT) with malignant transformation to squamous cell carcinoma are extremely rare, with only few cases reported in the literature. Herein, we report on a case of a primary sacrococcygeal mature cystic teratoma with malignant transformation into a squamous cell carcinoma. A 53-year-old woman presented with dysuria and lower abdominal pain caused by a huge SCT. Computed tomography (CT), magnetic resonance imaging, and positron emission tomography/CT findings were suggestive of SCT with malignant transformation. The treatment involved robotic-assisted laparoscopic abdominoperineal resection and bilateral lymph node dissection. Histopathology revealed squamous cell carcinoma within the teratoma. Postoperatively, the patient underwent six cycles of paclitaxel-carboplatin chemotherapy and showed no signs of recurrence during the 1-year follow-up.
KW - Malignant teratoma
KW - Sacrococcygeal region
KW - Squamous cell carcinoma
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U2 - 10.1016/j.hpr.2025.300773
DO - 10.1016/j.hpr.2025.300773
M3 - Article
AN - SCOPUS:105001353130
SN - 2772-736X
VL - 40
JO - Human Pathology Reports
JF - Human Pathology Reports
M1 - 300773
ER -