SPR-based DNA detection with metal nanoparticles

Kaoru Tamada, Fumio Nakamura, Masateru Ito, Xinheng Li, Akira Baba

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


In this short review paper, we summarize some of our ideas to utilize gold nanoparticles for the enhancement of surface plasmon resonance signals on DNA microarray. The hybridization of target-DNA capped gold nanoparticles with probe DNA on surface provides ca. ten times stronger optical contrast compared with that of target-DNA molecules. Our simulation result based on the Maxwell-Garnet theory explains well our experimental data and proves a potential of metallic nanoparticles for the substantial sensitivity enhancements for biosensor application in DNA diagnostics and bio-affinity studies, which leads to the fabrication of high resolution DNA microarrays.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
Issue number4
Publication statusPublished - Dec 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Biochemistry


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