Spontaneous self-assembly of nanospheres from trigonal conjugate of glutathione in water

Kazunori Matsuura; Hironori Matsuyama; Takashi Fukuda; Takeshi Teramoto; Kenta Watanabe; Kazuya Murasato; Nobuo Kimizuka

doi:10.1039/b819472f

Spontaneous self-assembly of nanospheres from trigonal conjugate of glutathione in water

Kazunori Matsuura, Hironori Matsuyama, Takashi Fukuda, Takeshi Teramoto, Kenta Watanabe, Kazuya Murasato, Nobuo Kimizuka

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

A novel C₃-symmetric peptide conjugate bearing three glutathione units (trigonal-glutathione, TG) was synthesized and its self-assembling behavior in water was studied by dynamic light scattering measurement, electron microscopy, and ¹H-NMR spectroscopy. In water, TG showed spontaneous self-assembly into nanospheres with the size of 100-250 nm. The size of TG assemblies is minimally affected by the concentration and pH. Concentration dependence of ¹H-NMR chemical shifts in D₂O revealed that TG is self-assembled by interactions between glutathione units (hydrogen bonding, electrostatic interactions) with an apparent association constant of K_a = 6.36 × 10³ M^-1. Concentration dependence of light scattering intensity and guest-binding ability indicated that the nanospheres underwent structural changes from hollow to filled spheres depending on the concentration.

Original language	English
Pages (from-to)	2463-2470
Number of pages	8
Journal	Soft Matter
Volume	5
Issue number	12
DOIs	https://doi.org/10.1039/b819472f
Publication status	Published - Jun 24 2009

All Science Journal Classification (ASJC) codes

Chemistry(all)
Condensed Matter Physics

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title = "Spontaneous self-assembly of nanospheres from trigonal conjugate of glutathione in water",

abstract = "A novel C3-symmetric peptide conjugate bearing three glutathione units (trigonal-glutathione, TG) was synthesized and its self-assembling behavior in water was studied by dynamic light scattering measurement, electron microscopy, and 1H-NMR spectroscopy. In water, TG showed spontaneous self-assembly into nanospheres with the size of 100-250 nm. The size of TG assemblies is minimally affected by the concentration and pH. Concentration dependence of 1H-NMR chemical shifts in D2O revealed that TG is self-assembled by interactions between glutathione units (hydrogen bonding, electrostatic interactions) with an apparent association constant of Ka = 6.36 × 103 M-1. Concentration dependence of light scattering intensity and guest-binding ability indicated that the nanospheres underwent structural changes from hollow to filled spheres depending on the concentration.",

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T1 - Spontaneous self-assembly of nanospheres from trigonal conjugate of glutathione in water

AU - Matsuura, Kazunori

AU - Matsuyama, Hironori

AU - Fukuda, Takashi

AU - Teramoto, Takeshi

AU - Watanabe, Kenta

AU - Murasato, Kazuya

AU - Kimizuka, Nobuo

PY - 2009/6/24

Y1 - 2009/6/24

N2 - A novel C3-symmetric peptide conjugate bearing three glutathione units (trigonal-glutathione, TG) was synthesized and its self-assembling behavior in water was studied by dynamic light scattering measurement, electron microscopy, and 1H-NMR spectroscopy. In water, TG showed spontaneous self-assembly into nanospheres with the size of 100-250 nm. The size of TG assemblies is minimally affected by the concentration and pH. Concentration dependence of 1H-NMR chemical shifts in D2O revealed that TG is self-assembled by interactions between glutathione units (hydrogen bonding, electrostatic interactions) with an apparent association constant of Ka = 6.36 × 103 M-1. Concentration dependence of light scattering intensity and guest-binding ability indicated that the nanospheres underwent structural changes from hollow to filled spheres depending on the concentration.

AB - A novel C3-symmetric peptide conjugate bearing three glutathione units (trigonal-glutathione, TG) was synthesized and its self-assembling behavior in water was studied by dynamic light scattering measurement, electron microscopy, and 1H-NMR spectroscopy. In water, TG showed spontaneous self-assembly into nanospheres with the size of 100-250 nm. The size of TG assemblies is minimally affected by the concentration and pH. Concentration dependence of 1H-NMR chemical shifts in D2O revealed that TG is self-assembled by interactions between glutathione units (hydrogen bonding, electrostatic interactions) with an apparent association constant of Ka = 6.36 × 103 M-1. Concentration dependence of light scattering intensity and guest-binding ability indicated that the nanospheres underwent structural changes from hollow to filled spheres depending on the concentration.

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Spontaneous self-assembly of nanospheres from trigonal conjugate of glutathione in water

Abstract

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