TY - JOUR
T1 - Spontaneous massive necrosis of hepatocellular carcinoma with narrowing and occlusion of the arteries and portal veins
AU - Tomino, Takahiro
AU - Yamashita, Yo Ichi
AU - Iguchi, Tomohiro
AU - Itoh, Shinji
AU - Ninomiya, Mizuki
AU - Ikegami, Toru
AU - Yoshizumi, Tomoharu
AU - Soejima, Yuji
AU - Kawanaka, Hirofumi
AU - Ikeda, Tetsuo
AU - Aishima, Shinichi
AU - Shirabe, Ken
AU - Maehara, Yoshihiko
PY - 2014
Y1 - 2014
N2 - We herein present the case of a 77-year-old man who had fever and right hypochondriac pain. He visited his doctor and underwent contrast computed tomography (CT), and he was suspected to have a liver abscess. He received an antibiotic treatment and his symptoms soon disappeared, but the tumor did not get smaller and its density on contrast CT image got stronger. He underwent biopsy and moderately differentiated hepatocellular carcinoma (HCC) was found. Extended left hepatic and caudate lobectomy was performed. Histological examination showed moderately differentiated HCC with narrowing and occlusion both in the arteries and portal veins associated with mild chronic inflammation. The mechanisms of spontaneous regression of HCC, such as immunological reactions and tumor hypoxia, have been proposed. In our case, histological examination showed the same findings. However, the mechanism is complex, and therefore further investigations are essential to elucidate it.
AB - We herein present the case of a 77-year-old man who had fever and right hypochondriac pain. He visited his doctor and underwent contrast computed tomography (CT), and he was suspected to have a liver abscess. He received an antibiotic treatment and his symptoms soon disappeared, but the tumor did not get smaller and its density on contrast CT image got stronger. He underwent biopsy and moderately differentiated hepatocellular carcinoma (HCC) was found. Extended left hepatic and caudate lobectomy was performed. Histological examination showed moderately differentiated HCC with narrowing and occlusion both in the arteries and portal veins associated with mild chronic inflammation. The mechanisms of spontaneous regression of HCC, such as immunological reactions and tumor hypoxia, have been proposed. In our case, histological examination showed the same findings. However, the mechanism is complex, and therefore further investigations are essential to elucidate it.
UR - http://www.scopus.com/inward/record.url?scp=84900484716&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84900484716&partnerID=8YFLogxK
U2 - 10.1159/000362440
DO - 10.1159/000362440
M3 - Article
AN - SCOPUS:84900484716
SN - 1662-0631
VL - 8
SP - 148
EP - 155
JO - Case Reports in Gastroenterology
JF - Case Reports in Gastroenterology
IS - 1
ER -